FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897066629> ?p ?o ?g. }

• W2897066629 abstract "Accumulation of amyloid beta (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD), which can be visualized using [18F]florbetapir positron emission tomography (PET). Accurate quantification of Aβ is important for monitoring both disease progression and response to disease modifying therapies. The aim of this study was to evaluate various parametric methods for voxel-by-voxel quantification of [18F]florbetapir binding and to assess their test-retest (TRT) reliability. Eight AD patients (age: 67±6) and eight controls (age: 63±4) were included. Two 90 minutes dynamic PET scans (Philips Ingenuity PET/CT), including arterial sampling, were acquired (∼4 weeks apart) after a bolus injection of 293±15 MBq [18F]florbetapir (specific activity: 4 μg/mL). Parametric images were generated using several linearization and basis function approaches (reference region: cerebellum grey matter). Logan and Spectral Analysis (SA) were used to generate volume of distribution (VT) images. Receptor parametric mapping (RPM), simplified reference tissue model with fixed k2’ (SRTM2), reference Logan (RLogan) and standardized uptake value ratios (SUVr(50-70)) were used to obtain binding potential (BPND) and SUVr(50-70) images. Regional BPND+1 and VT values were compared with corresponding DVR estimates derived from non-linear regression analysis using the plasma input two-tissue compartment (2T4k_VB) model (n=68 ROIs). TRT values (%) were obtained for both optimal parametric and SUVr(50-70) images. RPM (BPND+1) showed the least bias (r2=0.92; slope=0.91) compared to 2T4k_VB derived values. In addition, Logan (r2=0.94; slope=0.85) and RLogan (r2=0.92; slope=0.88), and SRTM2 (r2=0.92; slope=0.88) correlated well with their 2T4k_VB counterparts. Lower correlations were obtained for SUVr (r2=0.74; slope=0.90) and SA (r2=0.60; slope=0.81) with 2T4k_VB DVR and VT values. RPM (BPND+1) and SUVr(50-70) showed a TRT variation of 4.2% (controls: 2.6%, AD: 5.4%) and 8.8% (controls: 8.8%, AD: 8.9%), respectively. RPM was the parametric method of choice for [18F]florbetapir, combining the highest accuracy (lowest bias) with the best TRT reliability. Performance of the semi-quantitative SUVr approach was substantially poorer, especially with regards to TRT variability." @default.
• W2897066629 created "2018-10-26" @default.
• W2897066629 creator A5000907784 @default.
• W2897066629 creator A5003445744 @default.
• W2897066629 creator A5029713359 @default.
• W2897066629 creator A5032387052 @default.
• W2897066629 creator A5035267054 @default.
• W2897066629 creator A5037002032 @default.
• W2897066629 creator A5039782136 @default.
• W2897066629 creator A5047564828 @default.
• W2897066629 creator A5062198497 @default.
• W2897066629 creator A5065258380 @default.
• W2897066629 creator A5073943967 @default.
• W2897066629 creator A5075161586 @default.
• W2897066629 date "2018-07-01" @default.
• W2897066629 modified "2023-10-16" @default.
• W2897066629 title "P3‐438: PARAMETRIC IMAGING OF [ ¹⁸ F]FLORBETAPIR: A TEST‐RETEST STUDY IN HEALTHY SUBJECTS AND PATIENTS WITH ALZHEIMER'S DISEASE" @default.
• W2897066629 doi "https://doi.org/10.1016/j.jalz.2018.06.1801" @default.
• W2897066629 hasPublicationYear "2018" @default.
• W2897066629 type Work @default.
• W2897066629 sameAs 2897066629 @default.
• W2897066629 citedByCount "0" @default.
• W2897066629 crossrefType "journal-article" @default.
• W2897066629 hasAuthorship W2897066629A5000907784 @default.
• W2897066629 hasAuthorship W2897066629A5003445744 @default.
• W2897066629 hasAuthorship W2897066629A5029713359 @default.
• W2897066629 hasAuthorship W2897066629A5032387052 @default.
• W2897066629 hasAuthorship W2897066629A5035267054 @default.
• W2897066629 hasAuthorship W2897066629A5037002032 @default.
• W2897066629 hasAuthorship W2897066629A5039782136 @default.
• W2897066629 hasAuthorship W2897066629A5047564828 @default.
• W2897066629 hasAuthorship W2897066629A5062198497 @default.
• W2897066629 hasAuthorship W2897066629A5065258380 @default.
• W2897066629 hasAuthorship W2897066629A5073943967 @default.
• W2897066629 hasAuthorship W2897066629A5075161586 @default.
• W2897066629 hasConcept C105795698 @default.
• W2897066629 hasConcept C117251300 @default.
• W2897066629 hasConcept C126838900 @default.
• W2897066629 hasConcept C143409427 @default.
• W2897066629 hasConcept C199374082 @default.
• W2897066629 hasConcept C2775842073 @default.
• W2897066629 hasConcept C2989005 @default.
• W2897066629 hasConcept C33923547 @default.
• W2897066629 hasConcept C39313694 @default.
• W2897066629 hasConcept C54170458 @default.
• W2897066629 hasConcept C60592354 @default.
• W2897066629 hasConcept C71924100 @default.
• W2897066629 hasConceptScore W2897066629C105795698 @default.
• W2897066629 hasConceptScore W2897066629C117251300 @default.
• W2897066629 hasConceptScore W2897066629C126838900 @default.
• W2897066629 hasConceptScore W2897066629C143409427 @default.
• W2897066629 hasConceptScore W2897066629C199374082 @default.
• W2897066629 hasConceptScore W2897066629C2775842073 @default.
• W2897066629 hasConceptScore W2897066629C2989005 @default.
• W2897066629 hasConceptScore W2897066629C33923547 @default.
• W2897066629 hasConceptScore W2897066629C39313694 @default.
• W2897066629 hasConceptScore W2897066629C54170458 @default.
• W2897066629 hasConceptScore W2897066629C60592354 @default.
• W2897066629 hasConceptScore W2897066629C71924100 @default.
• W2897066629 hasIssue "7S_Part_24" @default.
• W2897066629 hasLocation W28970666291 @default.
• W2897066629 hasOpenAccess W2897066629 @default.
• W2897066629 hasPrimaryLocation W28970666291 @default.
• W2897066629 hasRelatedWork W1988429974 @default.
• W2897066629 hasRelatedWork W2004928237 @default.
• W2897066629 hasRelatedWork W2008779596 @default.
• W2897066629 hasRelatedWork W2026221058 @default.
• W2897066629 hasRelatedWork W2081690985 @default.
• W2897066629 hasRelatedWork W2134721386 @default.
• W2897066629 hasRelatedWork W2411005196 @default.
• W2897066629 hasRelatedWork W2937949475 @default.
• W2897066629 hasRelatedWork W4243649116 @default.
• W2897066629 hasRelatedWork W2903674688 @default.
• W2897066629 hasVolume "14" @default.
• W2897066629 isParatext "false" @default.
• W2897066629 isRetracted "false" @default.
• W2897066629 magId "2897066629" @default.
• W2897066629 workType "article" @default.