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• W2897073239 abstract "Abstract Mouse peritoneal macrophages consist of two subsets: large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), defined as CD11b hi F4/80 hi and CD11b + F4/80 lo cells, respectively. We reveal that SPMs, but not LPMs, have the ability to present antigens to naïve CD4 + T cells. Coculture of SPMs with naïve ovalbumin (OVA) specific CD4 + T cells (OT-II) in the presence of OVA peptide effectively induced CD4 + T cells priming. SPMs, but not LPMs, strongly express DNAM-1, an activating immunoreceptor. Although antigen uptake and processing were comparable between WT and DNAM-1-deficient SPMs, deficiency of DNAM-1 on SPMs or blockade of DNAM-1 and its ligand interaction impaired CD4 + T cells priming by SPMs. Furthermore, T and B cell responses in mediastinal lymph nodes of mice intraperitoneally immunized with trinitrophenyl (TNP)–OVA protein in Alum adjuvant were enhanced by intraperitoneally transferred wild-type, but not DNAM-1-deficient, SPMs. We propose that SPMs are functionally distinct from LPMs, and DNAM-1 plays a costimulatory role in antigen presentation by SPMs." @default.
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• W2897073239 date "2018-10-12" @default.
• W2897073239 modified "2023-10-15" @default.
• W2897073239 title "Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation" @default.
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• W2897073239 doi "https://doi.org/10.1038/s41598-018-33437-4" @default.
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