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• W2897075175 abstract "Being important representatives of various proteomes, membrane-active cationic peptides (CPs) are attractive objects as lead compounds in the design of new antibacterial, anticancer, antifungal, and antiviral molecules. Numerous CPs are found in insect and snake venoms, where many of them reveal cytolytic properties. Due to advances in omics technologies, the number of such peptides is growing dramatically. Areas covered: To understand structure-function relationships for CPs in a living cell, detailed analysis of their hydrophobic/hydrophilic properties is indispensable. We consider two structural classes of membrane-active CPs: latarcins (Ltc) from spider and cardiotoxins (CTXs) from snake venoms. While the former are void off disulfide bonds and conformationally flexible, the latter are structurally rigid and cross-linked with disulfide bonds. In order to elucidate structure-activity relationships behind their antibacterial, anticancer, and hemolytic effects, the properties of these polypeptides are considered on a side-by-side basis. Expert commentary: An ever-increasing number of venom-derived membrane-active polypeptides require new methods for identification of their functional propensities and sequence-based design of novel pharmacological substances. We address these issues considering a number of the designed peptides, based either on Ltc or CTX sequences. Experimental and computer modeling techniques required for these purposes are delineated." @default.
• W2897075175 created "2018-10-26" @default.
• W2897075175 creator A5000779538 @default.
• W2897075175 creator A5042443632 @default.
• W2897075175 date "2018-10-26" @default.
• W2897075175 modified "2023-09-24" @default.
• W2897075175 title "The role of hydrophobic /hydrophilic balance in the activity of structurally flexible vs. rigid cytolytic polypeptides and analogs developed on their basis" @default.
• W2897075175 cites W1187985466 @default.
• W2897075175 cites W1518360200 @default.
• W2897075175 cites W1522340948 @default.
• W2897075175 cites W1621833252 @default.
• W2897075175 cites W1766003632 @default.
• W2897075175 cites W1807395722 @default.
• W2897075175 cites W1848835470 @default.
• W2897075175 cites W190171142 @default.
• W2897075175 cites W1965102118 @default.
• W2897075175 cites W1969620914 @default.
• W2897075175 cites W1973742248 @default.
• W2897075175 cites W1976450928 @default.
• W2897075175 cites W1977235269 @default.
• W2897075175 cites W1977973749 @default.
• W2897075175 cites W1981312603 @default.
• W2897075175 cites W1984902900 @default.
• W2897075175 cites W1989394127 @default.
• W2897075175 cites W1990000747 @default.
• W2897075175 cites W1990733397 @default.
• W2897075175 cites W1994635293 @default.
• W2897075175 cites W1997368709 @default.
• W2897075175 cites W1997806381 @default.
• W2897075175 cites W2002195659 @default.
• W2897075175 cites W2004275010 @default.
• W2897075175 cites W2004790499 @default.
• W2897075175 cites W2009106357 @default.
• W2897075175 cites W2009909482 @default.
• W2897075175 cites W2009939017 @default.
• W2897075175 cites W2014254068 @default.
• W2897075175 cites W2014563096 @default.
• W2897075175 cites W2020328077 @default.
• W2897075175 cites W2022716427 @default.
• W2897075175 cites W2026740022 @default.
• W2897075175 cites W2030106420 @default.
• W2897075175 cites W2032162560 @default.
• W2897075175 cites W2033788948 @default.
• W2897075175 cites W2035074554 @default.
• W2897075175 cites W2035152794 @default.
• W2897075175 cites W2035552612 @default.
• W2897075175 cites W2036890861 @default.
• W2897075175 cites W2041710390 @default.
• W2897075175 cites W2042198735 @default.
• W2897075175 cites W2045192155 @default.
• W2897075175 cites W2045338471 @default.
• W2897075175 cites W2056823947 @default.
• W2897075175 cites W2061153213 @default.
• W2897075175 cites W2062537454 @default.
• W2897075175 cites W2064407933 @default.
• W2897075175 cites W2068481297 @default.
• W2897075175 cites W2069479820 @default.
• W2897075175 cites W2069962606 @default.
• W2897075175 cites W2074425608 @default.
• W2897075175 cites W2082624736 @default.
• W2897075175 cites W2083432094 @default.
• W2897075175 cites W2087085936 @default.
• W2897075175 cites W2093631934 @default.
• W2897075175 cites W2095894402 @default.
• W2897075175 cites W2100713689 @default.
• W2897075175 cites W2112212294 @default.
• W2897075175 cites W2116310119 @default.
• W2897075175 cites W2116817613 @default.
• W2897075175 cites W2116843129 @default.
• W2897075175 cites W2129115651 @default.
• W2897075175 cites W2129939988 @default.
• W2897075175 cites W2130387209 @default.
• W2897075175 cites W2135696719 @default.
• W2897075175 cites W2136007332 @default.
• W2897075175 cites W2144775514 @default.
• W2897075175 cites W2145207018 @default.
• W2897075175 cites W2148108043 @default.
• W2897075175 cites W2150467542 @default.
• W2897075175 cites W2154288481 @default.
• W2897075175 cites W2162776668 @default.
• W2897075175 cites W2165313287 @default.
• W2897075175 cites W2169746877 @default.
• W2897075175 cites W2170849801 @default.
• W2897075175 cites W2170912840 @default.
• W2897075175 cites W2171312987 @default.
• W2897075175 cites W2209148461 @default.
• W2897075175 cites W2219309337 @default.
• W2897075175 cites W2312508087 @default.
• W2897075175 cites W2325881917 @default.
• W2897075175 cites W2413370672 @default.
• W2897075175 cites W2417578947 @default.
• W2897075175 cites W2553035837 @default.
• W2897075175 cites W2555630365 @default.
• W2897075175 cites W2556828189 @default.
• W2897075175 cites W2562261325 @default.
• W2897075175 cites W2567937630 @default.
• W2897075175 cites W2584579518 @default.
• W2897075175 cites W2588436517 @default.

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