FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897079052> ?p ?o ?g. }

• W2897079052 endingPage "604" @default.
• W2897079052 startingPage "600" @default.
• W2897079052 abstract "Mechanisms that integrate the metabolic state of a cell with regulatory pathways are necessary to maintain cellular homeostasis. Endogenous, intrinsically reactive metabolites can form functional, covalent modifications on proteins without the aid of enzymes1,2, and regulate cellular functions such as metabolism3-5 and transcription6. An important 'sensor' protein that captures specific metabolic information and transforms it into an appropriate response is KEAP1, which contains reactive cysteine residues that collectively act as an electrophile sensor tuned to respond to reactive species resulting from endogenous and xenobiotic molecules. Covalent modification of KEAP1 results in reduced ubiquitination and the accumulation of NRF27,8, which then initiates the transcription of cytoprotective genes at antioxidant-response element loci. Here we identify a small-molecule inhibitor of the glycolytic enzyme PGK1, and reveal a direct link between glycolysis and NRF2 signalling. Inhibition of PGK1 results in accumulation of the reactive metabolite methylglyoxal, which selectively modifies KEAP1 to form a methylimidazole crosslink between proximal cysteine and arginine residues (MICA). This posttranslational modification results in the dimerization of KEAP1, the accumulation of NRF2 and activation of the NRF2 transcriptional program. These results demonstrate the existence of direct inter-pathway communication between glycolysis and the KEAP1-NRF2 transcriptional axis, provide insight into the metabolic regulation of the cellular stress response, and suggest a therapeutic strategy for controlling the cytoprotective antioxidant response in several human diseases." @default.
• W2897079052 created "2018-10-26" @default.
• W2897079052 creator A5004979527 @default.
• W2897079052 creator A5005596596 @default.
• W2897079052 creator A5005832805 @default.
• W2897079052 creator A5009038754 @default.
• W2897079052 creator A5016869942 @default.
• W2897079052 creator A5018005944 @default.
• W2897079052 creator A5047852347 @default.
• W2897079052 creator A5060471020 @default.
• W2897079052 creator A5066008654 @default.
• W2897079052 creator A5079207594 @default.
• W2897079052 creator A5079216637 @default.
• W2897079052 creator A5082353065 @default.
• W2897079052 date "2018-10-01" @default.
• W2897079052 modified "2023-10-03" @default.
• W2897079052 title "A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling" @default.
• W2897079052 cites W1597336200 @default.
• W2897079052 cites W1757241200 @default.
• W2897079052 cites W1969843775 @default.
• W2897079052 cites W1969899640 @default.
• W2897079052 cites W1981638513 @default.
• W2897079052 cites W1983743651 @default.
• W2897079052 cites W1991366673 @default.
• W2897079052 cites W1993251792 @default.
• W2897079052 cites W2004586101 @default.
• W2897079052 cites W2020393459 @default.
• W2897079052 cites W2022760167 @default.
• W2897079052 cites W2038468771 @default.
• W2897079052 cites W2040042255 @default.
• W2897079052 cites W2051278797 @default.
• W2897079052 cites W2053047691 @default.
• W2897079052 cites W2054988846 @default.
• W2897079052 cites W2076165765 @default.
• W2897079052 cites W2076972400 @default.
• W2897079052 cites W2082154183 @default.
• W2897079052 cites W2088030055 @default.
• W2897079052 cites W2120535614 @default.
• W2897079052 cites W2125762200 @default.
• W2897079052 cites W2130029858 @default.
• W2897079052 cites W2135426075 @default.
• W2897079052 cites W2138271341 @default.
• W2897079052 cites W2141982524 @default.
• W2897079052 cites W2152100400 @default.
• W2897079052 cites W2160358010 @default.
• W2897079052 cites W2161982997 @default.
• W2897079052 cites W2440556281 @default.
• W2897079052 cites W2501647650 @default.
• W2897079052 cites W2560129407 @default.
• W2897079052 cites W2571516067 @default.
• W2897079052 cites W2604275396 @default.
• W2897079052 cites W2789778824 @default.
• W2897079052 cites W2793196110 @default.
• W2897079052 doi "https://doi.org/10.1038/s41586-018-0622-0" @default.
• W2897079052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6444936" @default.
• W2897079052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323285" @default.
• W2897079052 hasPublicationYear "2018" @default.
• W2897079052 type Work @default.
• W2897079052 sameAs 2897079052 @default.
• W2897079052 citedByCount "183" @default.
• W2897079052 countsByYear W28970790522018 @default.
• W2897079052 countsByYear W28970790522019 @default.
• W2897079052 countsByYear W28970790522020 @default.
• W2897079052 countsByYear W28970790522021 @default.
• W2897079052 countsByYear W28970790522022 @default.
• W2897079052 countsByYear W28970790522023 @default.
• W2897079052 crossrefType "journal-article" @default.
• W2897079052 hasAuthorship W2897079052A5004979527 @default.
• W2897079052 hasAuthorship W2897079052A5005596596 @default.
• W2897079052 hasAuthorship W2897079052A5005832805 @default.
• W2897079052 hasAuthorship W2897079052A5009038754 @default.
• W2897079052 hasAuthorship W2897079052A5016869942 @default.
• W2897079052 hasAuthorship W2897079052A5018005944 @default.
• W2897079052 hasAuthorship W2897079052A5047852347 @default.
• W2897079052 hasAuthorship W2897079052A5060471020 @default.
• W2897079052 hasAuthorship W2897079052A5066008654 @default.
• W2897079052 hasAuthorship W2897079052A5079207594 @default.
• W2897079052 hasAuthorship W2897079052A5079216637 @default.
• W2897079052 hasAuthorship W2897079052A5082353065 @default.
• W2897079052 hasBestOaLocation W28970790522 @default.
• W2897079052 hasConcept C104317684 @default.
• W2897079052 hasConcept C161624437 @default.
• W2897079052 hasConcept C181199279 @default.
• W2897079052 hasConcept C185592680 @default.
• W2897079052 hasConcept C20251656 @default.
• W2897079052 hasConcept C25602115 @default.
• W2897079052 hasConcept C2776529522 @default.
• W2897079052 hasConcept C2778592357 @default.
• W2897079052 hasConcept C2779201268 @default.
• W2897079052 hasConcept C55493867 @default.
• W2897079052 hasConcept C86339819 @default.
• W2897079052 hasConcept C86803240 @default.
• W2897079052 hasConcept C95444343 @default.
• W2897079052 hasConceptScore W2897079052C104317684 @default.
• W2897079052 hasConceptScore W2897079052C161624437 @default.
• W2897079052 hasConceptScore W2897079052C181199279 @default.
• W2897079052 hasConceptScore W2897079052C185592680 @default.
• W2897079052 hasConceptScore W2897079052C20251656 @default.

• next