FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897085775> ?p ?o ?g. }

• W2897085775 endingPage "100024" @default.
• W2897085775 startingPage "100024" @default.
• W2897085775 abstract "Brain-derived neurotrophic factor (BDNF) signaling through its cognate receptor, TrkB, is a well-known promoter of synaptic plasticity at nociceptive synapses in the dorsal horn of the spinal cord. Existing evidence suggests that BDNF/TrkB signaling in neuropathic pain is sex dependent. We tested the hypothesis that the effects of BDNF/TrkB signaling in hyperalgesic priming might also be sexually dimorphic. Using the incision postsurgical pain model in male mice, we show that BDNF sequestration with TrkB-Fc administered at the time of surgery blocks the initiation and maintenance of hyperalgesic priming. However, when BDNF signaling was blocked prior to the precipitation of hyperalgesic priming with prostaglandin E2 (PGE2), priming was not reversed. This result is in contrast to our findings in male mice with interleukin-6 (IL6) as the priming stimulus where TrkB-Fc was effective in reversing the maintenance of hyperalgesic priming. Furthermore, in IL6-induced hyperalgesic priming, the BDNF sequestering agent, TrkB-fc, was effective in reversing the maintenance of hyperalgesic priming in male mice; however, when this experiment was conducted in female mice, we did not observe any effect of TrkB-fc. This markedly sexual dimorphic effect in mice is consistent with recent studies showing a similar effect in neuropathic pain models. We tested whether the sexual dimorphic role for BDNF was consistent across species. Importantly, we find that this sexual dimorphism does not occur in rats where TrkB-fc reverses hyperalgesic priming fully in both sexes. Finally, to determine the source of BDNF in hyperalgesic priming in mice, we used transgenic mice (Cx3cr1CreER × Bdnfflx/flx mice) with BDNF eliminated from microglia. From these experiments we conclude that BDNF from microglia does not contribute to hyperalgesic priming and that the key source of BDNF for hyperalgesic priming is likely nociceptors in the dorsal root ganglion. These experiments demonstrate the importance of testing mechanistic hypotheses in both sexes in multiple species to gain insight into complex biology underlying chronic pain." @default.
• W2897085775 created "2018-10-26" @default.
• W2897085775 creator A5024187988 @default.
• W2897085775 creator A5034449671 @default.
• W2897085775 creator A5036070814 @default.
• W2897085775 creator A5040294572 @default.
• W2897085775 creator A5054657976 @default.
• W2897085775 creator A5056024832 @default.
• W2897085775 creator A5065183811 @default.
• W2897085775 creator A5076846499 @default.
• W2897085775 creator A5079356211 @default.
• W2897085775 creator A5089248547 @default.
• W2897085775 date "2019-01-01" @default.
• W2897085775 modified "2023-10-15" @default.
• W2897085775 title "Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats" @default.
• W2897085775 cites W1568010017 @default.
• W2897085775 cites W193867833 @default.
• W2897085775 cites W1976201689 @default.
• W2897085775 cites W1977924327 @default.
• W2897085775 cites W2002991319 @default.
• W2897085775 cites W2030076800 @default.
• W2897085775 cites W2040642697 @default.
• W2897085775 cites W2051118171 @default.
• W2897085775 cites W2055755492 @default.
• W2897085775 cites W2066413192 @default.
• W2897085775 cites W2067040581 @default.
• W2897085775 cites W2087102666 @default.
• W2897085775 cites W2087191156 @default.
• W2897085775 cites W2089236266 @default.
• W2897085775 cites W2113138572 @default.
• W2897085775 cites W2119959037 @default.
• W2897085775 cites W2128994172 @default.
• W2897085775 cites W2132247478 @default.
• W2897085775 cites W2134907255 @default.
• W2897085775 cites W2137055184 @default.
• W2897085775 cites W2156947921 @default.
• W2897085775 cites W2170576851 @default.
• W2897085775 cites W2172201406 @default.
• W2897085775 cites W2195259275 @default.
• W2897085775 cites W2196308323 @default.
• W2897085775 cites W2315924674 @default.
• W2897085775 cites W2507140532 @default.
• W2897085775 cites W2520612158 @default.
• W2897085775 cites W2556483487 @default.
• W2897085775 cites W260187207 @default.
• W2897085775 cites W2614692629 @default.
• W2897085775 cites W2727220925 @default.
• W2897085775 cites W2735955539 @default.
• W2897085775 cites W2767325098 @default.
• W2897085775 cites W2769750184 @default.
• W2897085775 cites W2776476861 @default.
• W2897085775 cites W2790997755 @default.
• W2897085775 cites W2793593473 @default.
• W2897085775 cites W2800006084 @default.
• W2897085775 cites W2803929023 @default.
• W2897085775 cites W2808142464 @default.
• W2897085775 cites W2808882111 @default.
• W2897085775 cites W2808885684 @default.
• W2897085775 cites W2809386188 @default.
• W2897085775 doi "https://doi.org/10.1016/j.ynpai.2018.10.001" @default.
• W2897085775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6550116" @default.
• W2897085775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31194015" @default.
• W2897085775 hasPublicationYear "2019" @default.
• W2897085775 type Work @default.
• W2897085775 sameAs 2897085775 @default.
• W2897085775 citedByCount "21" @default.
• W2897085775 countsByYear W28970857752019 @default.
• W2897085775 countsByYear W28970857752020 @default.
• W2897085775 countsByYear W28970857752021 @default.
• W2897085775 countsByYear W28970857752022 @default.
• W2897085775 countsByYear W28970857752023 @default.
• W2897085775 crossrefType "journal-article" @default.
• W2897085775 hasAuthorship W2897085775A5024187988 @default.
• W2897085775 hasAuthorship W2897085775A5034449671 @default.
• W2897085775 hasAuthorship W2897085775A5036070814 @default.
• W2897085775 hasAuthorship W2897085775A5040294572 @default.
• W2897085775 hasAuthorship W2897085775A5054657976 @default.
• W2897085775 hasAuthorship W2897085775A5056024832 @default.
• W2897085775 hasAuthorship W2897085775A5065183811 @default.
• W2897085775 hasAuthorship W2897085775A5076846499 @default.
• W2897085775 hasAuthorship W2897085775A5079356211 @default.
• W2897085775 hasAuthorship W2897085775A5089248547 @default.
• W2897085775 hasBestOaLocation W28970857751 @default.
• W2897085775 hasConcept C100701293 @default.
• W2897085775 hasConcept C126322002 @default.
• W2897085775 hasConcept C134018914 @default.
• W2897085775 hasConcept C15490471 @default.
• W2897085775 hasConcept C15744967 @default.
• W2897085775 hasConcept C160539049 @default.
• W2897085775 hasConcept C169760540 @default.
• W2897085775 hasConcept C170493617 @default.
• W2897085775 hasConcept C171034665 @default.
• W2897085775 hasConcept C172659308 @default.
• W2897085775 hasConcept C2777107010 @default.
• W2897085775 hasConcept C2778790584 @default.
• W2897085775 hasConcept C59822182 @default.
• W2897085775 hasConcept C71924100 @default.
• W2897085775 hasConcept C81444415 @default.

• next