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- W2897085786 abstract "Double-blind RCTs are viewed as the gold standard in eliminating placebo effects and identifying non-placebo physiological effects. Expectancy theory posits that subjects have better present health in response to better expected future health. We show that if subjects Bayesian update about efficacy based upon physiological responses during a single-stage RCT, expected placebo effects are generally unequal across treatment and control groups. Thus, the difference between mean health across treatment and control groups is a biased estimator of the mean non-placebo physiological effect. RCTs featuring low treatment probabilities are robust: Bias approaches zero as the treated group measure approaches zero." @default.
- W2897085786 created "2018-10-26" @default.
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- W2897085786 date "2017-01-01" @default.
- W2897085786 modified "2023-09-27" @default.
- W2897085786 title "Subject Rational Expectations Will Contaminate Randomized Controlled Medical Trials" @default.
- W2897085786 doi "https://doi.org/10.2139/ssrn.2800265" @default.
- W2897085786 hasPublicationYear "2017" @default.
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