FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897087893> ?p ?o ?g. }

• W2897087893 abstract "Septapeptides (“septas”), previously identified as meningitis-specific antigens, defined by a rubella virus monoclonal antibody, were found in human Monocyte Chemoattractant Protein (hMCP-1) and on the surface of meningitis-causing bacteria, viruses and spirochetes.1-3 Some bacterial septas were tested for Ca+2 mobilization through receptor-associated heterotrimeric G-protein binding on THP-1 cells, progenitor cells of circulating peripheral macrophages. Certain of the free septas acted on their own as mild agonists of Ca+2 mobilization. Their signal transduction activity may be mediated through a single (or a single class) of receptor, but the data do not link this with the MCP-1 receptor on THP-1 cells. These data support the notion that (1) infectious organisms may conserve and employ these sequences in order to facilitate their transport through the BBB to infect the CNS and (2) the hypothesis that the septas represent muteins of the MCP-1 active site for monocyte stem cell activation to macrophages. Other MCP muteins have since been identified in the AD-associated agents, amyloid beta and prions, as well as in viruses like HIV, known to establish chronic infections in the CNS. Rat glial progenitor cells in tissue culture 4-6 were used to test for hMCP-1 activity in septas derived from amyloid beta. Nanomolar concentrations of the amyloid beta septa 13HHQKLVF19 were found to transform more than 60% of rat glial progenitor cells into mature microglia in tissue culture7.8. These data support the hypothesis that an amyloid beta-derived septa may serve to activate stem cells to increase the number of microglia available to combat chronic infection in the CNS. 1VanAlstyne & Sharma. April 23, 1996. US Patent No. 5,510,264. 2VanAlstyne & Sharma. Sept. 17, 1996. US Patent No. 5,556,757. 3Van Alstyne & Sharma. Dec. 6, 2011. US Patent No. 8,071,102. 4Singh and Van Alstyne. 1978.Brain Res. 155:418-421. 5Pope and Van Alstyne. 1981.Virology 113(2):776-780. 6Van Alstyne and Paty. 1983.Virology 124:173-180 7Van Alstyne, Jan. 4, 2018. US Patent Application 62/613,621. 8Van Alstyne. June 20, 2018 Poster(3035) presentation at Keystone Symposia Conference “Advances in Neurodegenerative Disease Research and Therapy”. Session Z3." @default.
• W2897087893 created "2018-10-26" @default.
• W2897087893 creator A5004391286 @default.
• W2897087893 date "2018-07-01" @default.
• W2897087893 modified "2023-10-16" @default.
• W2897087893 title "P4‐228: AN AMYLOID‐BETA‐DERIVED PEPTIDE TRANSFORMS RAT GLIAL PROGENITOR CELLS INTO MICROGLIA" @default.
• W2897087893 doi "https://doi.org/10.1016/j.jalz.2018.07.049" @default.
• W2897087893 hasPublicationYear "2018" @default.
• W2897087893 type Work @default.
• W2897087893 sameAs 2897087893 @default.
• W2897087893 citedByCount "0" @default.
• W2897087893 crossrefType "journal-article" @default.
• W2897087893 hasAuthorship W2897087893A5004391286 @default.
• W2897087893 hasConcept C170493617 @default.
• W2897087893 hasConcept C201750760 @default.
• W2897087893 hasConcept C203014093 @default.
• W2897087893 hasConcept C2776914184 @default.
• W2897087893 hasConcept C2779830541 @default.
• W2897087893 hasConcept C2781184567 @default.
• W2897087893 hasConcept C28328180 @default.
• W2897087893 hasConcept C54166955 @default.
• W2897087893 hasConcept C55493867 @default.
• W2897087893 hasConcept C86803240 @default.
• W2897087893 hasConcept C95444343 @default.
• W2897087893 hasConceptScore W2897087893C170493617 @default.
• W2897087893 hasConceptScore W2897087893C201750760 @default.
• W2897087893 hasConceptScore W2897087893C203014093 @default.
• W2897087893 hasConceptScore W2897087893C2776914184 @default.
• W2897087893 hasConceptScore W2897087893C2779830541 @default.
• W2897087893 hasConceptScore W2897087893C2781184567 @default.
• W2897087893 hasConceptScore W2897087893C28328180 @default.
• W2897087893 hasConceptScore W2897087893C54166955 @default.
• W2897087893 hasConceptScore W2897087893C55493867 @default.
• W2897087893 hasConceptScore W2897087893C86803240 @default.
• W2897087893 hasConceptScore W2897087893C95444343 @default.
• W2897087893 hasIssue "7S_Part_29" @default.
• W2897087893 hasLocation W28970878931 @default.
• W2897087893 hasOpenAccess W2897087893 @default.
• W2897087893 hasPrimaryLocation W28970878931 @default.
• W2897087893 hasRelatedWork W1511540498 @default.
• W2897087893 hasRelatedWork W1933245301 @default.
• W2897087893 hasRelatedWork W2024585522 @default.
• W2897087893 hasRelatedWork W2090544000 @default.
• W2897087893 hasRelatedWork W2099233769 @default.
• W2897087893 hasRelatedWork W2133971264 @default.
• W2897087893 hasRelatedWork W2135793203 @default.
• W2897087893 hasRelatedWork W2189366241 @default.
• W2897087893 hasRelatedWork W2300366807 @default.
• W2897087893 hasRelatedWork W3213450778 @default.
• W2897087893 hasVolume "14" @default.
• W2897087893 isParatext "false" @default.
• W2897087893 isRetracted "false" @default.
• W2897087893 magId "2897087893" @default.
• W2897087893 workType "article" @default.