Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897088623> ?p ?o ?g. }
- W2897088623 endingPage "640" @default.
- W2897088623 startingPage "631" @default.
- W2897088623 abstract "Influenza remains an important threat for human health, despite the extensive study of influenza viruses and the production of effective vaccines. In contrast to virus genetics determinants, host genetic factors with clinical impact remained unexplored until recently. The association between three single nucleotide polymorphisms (SNPs) and influenza outcome in a European population was investigated in the present study. All samples were collected during the influenza A(H1N1)pdm09 post-pandemic period 2010–11 and a sufficient number of severe and fatal cases was included. Host genomic DNA was isolated from pharyngeal samples of 110 patients from northern Greece with severe (n = 59) or mild (n = 51) influenza A(H1N1)pdm09 disease, at baseline, and the genotype of CD55 rs2564978, C1QBP rs3786054 and FCGR2A rs1801274 SNPs was investigated. Our findings suggest a relationship between the two complement-related SNPs, namely, the rare TT genotype of CD55 and the rare AA genotype of C1QBP with increased death risk. No significant differences were observed for FCGR2A genotypes neither with fatality nor disease severity. Additional large-scale genetic association studies are necessary for the identification of reliable host genetic risk factors associated with influenza A(H1N1)pdm09 outcome. Prophylactic intervention of additional high-risk populations, according to their genetic profile, will be a key achievement for the fight against influenza viruses." @default.
- W2897088623 created "2018-10-26" @default.
- W2897088623 creator A5045931961 @default.
- W2897088623 creator A5052144015 @default.
- W2897088623 creator A5063004210 @default.
- W2897088623 creator A5080651334 @default.
- W2897088623 creator A5087236359 @default.
- W2897088623 date "2018-10-10" @default.
- W2897088623 modified "2023-09-30" @default.
- W2897088623 title "Identification of complement-related host genetic risk factors associated with influenza A(H1N1)pdm09 outcome: challenges ahead" @default.
- W2897088623 cites W1966313070 @default.
- W2897088623 cites W1967113354 @default.
- W2897088623 cites W1971531415 @default.
- W2897088623 cites W2003988251 @default.
- W2897088623 cites W2006404788 @default.
- W2897088623 cites W2008713419 @default.
- W2897088623 cites W2025145799 @default.
- W2897088623 cites W2033912881 @default.
- W2897088623 cites W2050032631 @default.
- W2897088623 cites W2052385416 @default.
- W2897088623 cites W2053673793 @default.
- W2897088623 cites W2061008984 @default.
- W2897088623 cites W2068353535 @default.
- W2897088623 cites W2068592034 @default.
- W2897088623 cites W2070924692 @default.
- W2897088623 cites W2073625279 @default.
- W2897088623 cites W2084271278 @default.
- W2897088623 cites W2088788062 @default.
- W2897088623 cites W2097678459 @default.
- W2897088623 cites W2105025553 @default.
- W2897088623 cites W2106460540 @default.
- W2897088623 cites W2107916366 @default.
- W2897088623 cites W2114421191 @default.
- W2897088623 cites W2114526758 @default.
- W2897088623 cites W2118904881 @default.
- W2897088623 cites W2119603672 @default.
- W2897088623 cites W2121368319 @default.
- W2897088623 cites W2133979383 @default.
- W2897088623 cites W2149378058 @default.
- W2897088623 cites W2201099545 @default.
- W2897088623 cites W2213491359 @default.
- W2897088623 cites W2397088848 @default.
- W2897088623 cites W2410767986 @default.
- W2897088623 cites W2462549711 @default.
- W2897088623 cites W2564608994 @default.
- W2897088623 cites W2614719394 @default.
- W2897088623 cites W4301966542 @default.
- W2897088623 cites W621174895 @default.
- W2897088623 doi "https://doi.org/10.1007/s00430-018-0567-9" @default.
- W2897088623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7102177" @default.
- W2897088623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30306260" @default.
- W2897088623 hasPublicationYear "2018" @default.
- W2897088623 type Work @default.
- W2897088623 sameAs 2897088623 @default.
- W2897088623 citedByCount "12" @default.
- W2897088623 countsByYear W28970886232019 @default.
- W2897088623 countsByYear W28970886232020 @default.
- W2897088623 countsByYear W28970886232021 @default.
- W2897088623 countsByYear W28970886232023 @default.
- W2897088623 crossrefType "journal-article" @default.
- W2897088623 hasAuthorship W2897088623A5045931961 @default.
- W2897088623 hasAuthorship W2897088623A5052144015 @default.
- W2897088623 hasAuthorship W2897088623A5063004210 @default.
- W2897088623 hasAuthorship W2897088623A5080651334 @default.
- W2897088623 hasAuthorship W2897088623A5087236359 @default.
- W2897088623 hasBestOaLocation W28970886232 @default.
- W2897088623 hasConcept C104317684 @default.
- W2897088623 hasConcept C126322002 @default.
- W2897088623 hasConcept C135763542 @default.
- W2897088623 hasConcept C153209595 @default.
- W2897088623 hasConcept C159047783 @default.
- W2897088623 hasConcept C190139176 @default.
- W2897088623 hasConcept C203014093 @default.
- W2897088623 hasConcept C2522874641 @default.
- W2897088623 hasConcept C2777546802 @default.
- W2897088623 hasConcept C2779134260 @default.
- W2897088623 hasConcept C2908647359 @default.
- W2897088623 hasConcept C54355233 @default.
- W2897088623 hasConcept C71924100 @default.
- W2897088623 hasConcept C86803240 @default.
- W2897088623 hasConcept C99454951 @default.
- W2897088623 hasConceptScore W2897088623C104317684 @default.
- W2897088623 hasConceptScore W2897088623C126322002 @default.
- W2897088623 hasConceptScore W2897088623C135763542 @default.
- W2897088623 hasConceptScore W2897088623C153209595 @default.
- W2897088623 hasConceptScore W2897088623C159047783 @default.
- W2897088623 hasConceptScore W2897088623C190139176 @default.
- W2897088623 hasConceptScore W2897088623C203014093 @default.
- W2897088623 hasConceptScore W2897088623C2522874641 @default.
- W2897088623 hasConceptScore W2897088623C2777546802 @default.
- W2897088623 hasConceptScore W2897088623C2779134260 @default.
- W2897088623 hasConceptScore W2897088623C2908647359 @default.
- W2897088623 hasConceptScore W2897088623C54355233 @default.
- W2897088623 hasConceptScore W2897088623C71924100 @default.
- W2897088623 hasConceptScore W2897088623C86803240 @default.
- W2897088623 hasConceptScore W2897088623C99454951 @default.
- W2897088623 hasIssue "5" @default.
- W2897088623 hasLocation W28970886231 @default.