Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897089826> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2897089826 endingPage "718" @default.
- W2897089826 startingPage "710" @default.
- W2897089826 abstract "We present an application of a quantitative systems pharmacology ( QSP ) model to support a regulatory decision, specifically in assessing the adequacy of the proposed dosing regimen. On January 23, 2015, the US Food and Drug Administration ( FDA ) approved Natpara (human parathyroid hormone ( PTH )) to control hypocalcemia in patients with hypoparathyroidism. Clinical trial results indicated that although once‐daily PTH reduced calcium and vitamin D dose requirement while maintaining the normocalcemia, the regimen was not adequate to control hypercalciuria. We hypothesized that the lack of control on urinary calcium excretion was due to the short half‐life of PTH . The QSP model‐based simulations indicated that a more frequent dosing regimen may provide better control on hypercalciuria while maintaining normocalcemia. A postmarketing trial was recommended to assess pharmacokinetics (PKs) and pharmacodynamics (PDs) of PTH dose and dosing regimen. Although other modeling approaches may be feasible, in this specific case, QSP model‐based simulations fulfilled the information gap to support recommendations of this postmarketing trial." @default.
- W2897089826 created "2018-10-26" @default.
- W2897089826 creator A5002523374 @default.
- W2897089826 creator A5012892785 @default.
- W2897089826 creator A5016879216 @default.
- W2897089826 creator A5028489187 @default.
- W2897089826 creator A5046914865 @default.
- W2897089826 creator A5047920902 @default.
- W2897089826 creator A5055092814 @default.
- W2897089826 creator A5064564309 @default.
- W2897089826 creator A5065026937 @default.
- W2897089826 creator A5075372396 @default.
- W2897089826 date "2018-10-22" @default.
- W2897089826 modified "2023-09-25" @default.
- W2897089826 title "Use of a Systems Pharmacology Model Based Approach Toward Dose Optimization of Parathyroid Hormone Therapy in Hypoparathyroidism" @default.
- W2897089826 cites W1949005468 @default.
- W2897089826 cites W1972602991 @default.
- W2897089826 cites W1980556433 @default.
- W2897089826 cites W1989609029 @default.
- W2897089826 cites W2009899605 @default.
- W2897089826 cites W2022896158 @default.
- W2897089826 cites W2039970252 @default.
- W2897089826 cites W2053368225 @default.
- W2897089826 cites W2053701337 @default.
- W2897089826 cites W2074383353 @default.
- W2897089826 cites W2099098863 @default.
- W2897089826 cites W2118479851 @default.
- W2897089826 cites W2127955916 @default.
- W2897089826 cites W2401962735 @default.
- W2897089826 cites W4239366016 @default.
- W2897089826 doi "https://doi.org/10.1002/cpt.1200" @default.
- W2897089826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350311" @default.
- W2897089826 hasPublicationYear "2018" @default.
- W2897089826 type Work @default.
- W2897089826 sameAs 2897089826 @default.
- W2897089826 citedByCount "9" @default.
- W2897089826 countsByYear W28970898262019 @default.
- W2897089826 countsByYear W28970898262020 @default.
- W2897089826 countsByYear W28970898262022 @default.
- W2897089826 countsByYear W28970898262023 @default.
- W2897089826 crossrefType "journal-article" @default.
- W2897089826 hasAuthorship W2897089826A5002523374 @default.
- W2897089826 hasAuthorship W2897089826A5012892785 @default.
- W2897089826 hasAuthorship W2897089826A5016879216 @default.
- W2897089826 hasAuthorship W2897089826A5028489187 @default.
- W2897089826 hasAuthorship W2897089826A5046914865 @default.
- W2897089826 hasAuthorship W2897089826A5047920902 @default.
- W2897089826 hasAuthorship W2897089826A5055092814 @default.
- W2897089826 hasAuthorship W2897089826A5064564309 @default.
- W2897089826 hasAuthorship W2897089826A5065026937 @default.
- W2897089826 hasAuthorship W2897089826A5075372396 @default.
- W2897089826 hasConcept C111113717 @default.
- W2897089826 hasConcept C112705442 @default.
- W2897089826 hasConcept C126322002 @default.
- W2897089826 hasConcept C2775941721 @default.
- W2897089826 hasConcept C2777288759 @default.
- W2897089826 hasConcept C2777724520 @default.
- W2897089826 hasConcept C2781208988 @default.
- W2897089826 hasConcept C2781413609 @default.
- W2897089826 hasConcept C519063684 @default.
- W2897089826 hasConcept C71924100 @default.
- W2897089826 hasConcept C98274493 @default.
- W2897089826 hasConceptScore W2897089826C111113717 @default.
- W2897089826 hasConceptScore W2897089826C112705442 @default.
- W2897089826 hasConceptScore W2897089826C126322002 @default.
- W2897089826 hasConceptScore W2897089826C2775941721 @default.
- W2897089826 hasConceptScore W2897089826C2777288759 @default.
- W2897089826 hasConceptScore W2897089826C2777724520 @default.
- W2897089826 hasConceptScore W2897089826C2781208988 @default.
- W2897089826 hasConceptScore W2897089826C2781413609 @default.
- W2897089826 hasConceptScore W2897089826C519063684 @default.
- W2897089826 hasConceptScore W2897089826C71924100 @default.
- W2897089826 hasConceptScore W2897089826C98274493 @default.
- W2897089826 hasIssue "3" @default.
- W2897089826 hasLocation W28970898261 @default.
- W2897089826 hasLocation W28970898262 @default.
- W2897089826 hasOpenAccess W2897089826 @default.
- W2897089826 hasPrimaryLocation W28970898261 @default.
- W2897089826 hasRelatedWork W1976159180 @default.
- W2897089826 hasRelatedWork W2004325424 @default.
- W2897089826 hasRelatedWork W2021319218 @default.
- W2897089826 hasRelatedWork W2227061539 @default.
- W2897089826 hasRelatedWork W2245370565 @default.
- W2897089826 hasRelatedWork W2400384365 @default.
- W2897089826 hasRelatedWork W2594910449 @default.
- W2897089826 hasRelatedWork W2992709639 @default.
- W2897089826 hasRelatedWork W3021369409 @default.
- W2897089826 hasRelatedWork W3174177415 @default.
- W2897089826 hasVolume "105" @default.
- W2897089826 isParatext "false" @default.
- W2897089826 isRetracted "false" @default.
- W2897089826 magId "2897089826" @default.
- W2897089826 workType "article" @default.