Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897092159> ?p ?o ?g. }
- W2897092159 endingPage "40" @default.
- W2897092159 startingPage "31" @default.
- W2897092159 abstract "This study investigated the effect of acylated ghrelin (AG) deficiency after sleeve gastrectomy (SG) or chronic administration in control and SG-indiuced rats on platelet function, coagulation, and fibrinolysis. Administration of AG (100 µg/kg, subcutaneously) to control or SG rats significantly inhibited platelets aggregation and lowered levels of Von-Willebrand factor (vWF), fibrinogen, and thromboxane B2. Concomitantly, it decreased circulatory levels and aortic expression levels of plasminogen activator inhibitor-1 (PAI-1) and tissue factor (TF) and increased the aortic expression of the endothelial nitric oxidase (eNOS). However, AG inhibited angiotensin-II (ANGII)-induced upregulation of tissue factor pathway inhibitor (TPAI) and TF and increased activity of TF and increases eNOS expression in cultured endothelial cells, an effect that was abolished by the addition of D-[lys3]-GHRP-6, a selective AG receptor (GHSR-1a) blocker or L-Name, a potent eNOS inhibitor. In conclusion, AG has an anti-platelet, anti-coagulant, and fibrinolytic roles mediated through GHSR-1a to enhance nitric oxide synthesis." @default.
- W2897092159 created "2018-10-26" @default.
- W2897092159 creator A5005784355 @default.
- W2897092159 date "2018-10-15" @default.
- W2897092159 modified "2023-09-25" @default.
- W2897092159 title "Hemostatic effect of acylated ghrelin in control and sleeve gastrectomy-induced rats: mechanisms of action" @default.
- W2897092159 cites W1554351458 @default.
- W2897092159 cites W1973121188 @default.
- W2897092159 cites W1973807604 @default.
- W2897092159 cites W1990384980 @default.
- W2897092159 cites W1991848956 @default.
- W2897092159 cites W2007588822 @default.
- W2897092159 cites W2007762511 @default.
- W2897092159 cites W2014104163 @default.
- W2897092159 cites W2014159666 @default.
- W2897092159 cites W2019190598 @default.
- W2897092159 cites W2020702043 @default.
- W2897092159 cites W2028752055 @default.
- W2897092159 cites W2031297495 @default.
- W2897092159 cites W2035816915 @default.
- W2897092159 cites W2036021417 @default.
- W2897092159 cites W2036463603 @default.
- W2897092159 cites W2052818567 @default.
- W2897092159 cites W2058157135 @default.
- W2897092159 cites W2066445008 @default.
- W2897092159 cites W2068886931 @default.
- W2897092159 cites W2083090431 @default.
- W2897092159 cites W2087458459 @default.
- W2897092159 cites W2090094198 @default.
- W2897092159 cites W2094342438 @default.
- W2897092159 cites W2099823649 @default.
- W2897092159 cites W2110402443 @default.
- W2897092159 cites W2110467673 @default.
- W2897092159 cites W2113199324 @default.
- W2897092159 cites W2117996963 @default.
- W2897092159 cites W2119129191 @default.
- W2897092159 cites W2123626152 @default.
- W2897092159 cites W2129389766 @default.
- W2897092159 cites W2129420064 @default.
- W2897092159 cites W2136057525 @default.
- W2897092159 cites W2148750921 @default.
- W2897092159 cites W2148924156 @default.
- W2897092159 cites W2155478471 @default.
- W2897092159 cites W2157049105 @default.
- W2897092159 cites W2168601664 @default.
- W2897092159 cites W2180718538 @default.
- W2897092159 cites W2191385376 @default.
- W2897092159 cites W2790313983 @default.
- W2897092159 cites W4251527986 @default.
- W2897092159 doi "https://doi.org/10.1080/13813455.2018.1489849" @default.
- W2897092159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320517" @default.
- W2897092159 hasPublicationYear "2018" @default.
- W2897092159 type Work @default.
- W2897092159 sameAs 2897092159 @default.
- W2897092159 citedByCount "1" @default.
- W2897092159 countsByYear W28970921592021 @default.
- W2897092159 crossrefType "journal-article" @default.
- W2897092159 hasAuthorship W2897092159A5005784355 @default.
- W2897092159 hasConcept C104317684 @default.
- W2897092159 hasConcept C126322002 @default.
- W2897092159 hasConcept C127561419 @default.
- W2897092159 hasConcept C134018914 @default.
- W2897092159 hasConcept C170493617 @default.
- W2897092159 hasConcept C185592680 @default.
- W2897092159 hasConcept C186738567 @default.
- W2897092159 hasConcept C2776825266 @default.
- W2897092159 hasConcept C2777151630 @default.
- W2897092159 hasConcept C2777622882 @default.
- W2897092159 hasConcept C2778326061 @default.
- W2897092159 hasConcept C2778382381 @default.
- W2897092159 hasConcept C2779357093 @default.
- W2897092159 hasConcept C2779394231 @default.
- W2897092159 hasConcept C2779679481 @default.
- W2897092159 hasConcept C2780675426 @default.
- W2897092159 hasConcept C2781128415 @default.
- W2897092159 hasConcept C519581460 @default.
- W2897092159 hasConcept C55493867 @default.
- W2897092159 hasConcept C71924100 @default.
- W2897092159 hasConcept C89560881 @default.
- W2897092159 hasConceptScore W2897092159C104317684 @default.
- W2897092159 hasConceptScore W2897092159C126322002 @default.
- W2897092159 hasConceptScore W2897092159C127561419 @default.
- W2897092159 hasConceptScore W2897092159C134018914 @default.
- W2897092159 hasConceptScore W2897092159C170493617 @default.
- W2897092159 hasConceptScore W2897092159C185592680 @default.
- W2897092159 hasConceptScore W2897092159C186738567 @default.
- W2897092159 hasConceptScore W2897092159C2776825266 @default.
- W2897092159 hasConceptScore W2897092159C2777151630 @default.
- W2897092159 hasConceptScore W2897092159C2777622882 @default.
- W2897092159 hasConceptScore W2897092159C2778326061 @default.
- W2897092159 hasConceptScore W2897092159C2778382381 @default.
- W2897092159 hasConceptScore W2897092159C2779357093 @default.
- W2897092159 hasConceptScore W2897092159C2779394231 @default.
- W2897092159 hasConceptScore W2897092159C2779679481 @default.
- W2897092159 hasConceptScore W2897092159C2780675426 @default.
- W2897092159 hasConceptScore W2897092159C2781128415 @default.
- W2897092159 hasConceptScore W2897092159C519581460 @default.
- W2897092159 hasConceptScore W2897092159C55493867 @default.