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- W2897092521 abstract "The search for additional genetic risk factors for Alzheimer's disease (AD) requires novel dataset and populations. The Genome Research program at Fundacio ACE (GR@ACE, Barcelona, Spain), represents a new effort to study of AD susceptibility. The GR@ACE study comprises 7,464 unrelated individuals. 4,116 AD cases were diagnosed at Fundació ACE Memory Clinic (Barcelona, Spain). 3,348 Controls were obtained from three collections (Fundació ACE, Barcelona; DNA National Biobank, Salamanca and HU Valme, Seville). Genotyping was carried out using the 815K Axiom Spain Biobank array (Affymetrix.) in the national center for genotyping (CEGEN, Santiago de Compostela, Spain). After genotyping, an extensive quality control was conducted, including re-sampling, gender match, stratification, relatedness, heterozygosity, differential missingness and HWD analyses. 14 million SNPs were imputed using the HRC panel. Obtained results were analyzed applying the dosage method (PLINK software) and different association models. Principal component analyses revealed a homogenous population matching with south Europeans. Association studies revealed suggestive loci (p < 1.00−6) at chr10q22.1, chr4q34 and chr5p15.1 chromosomal regions. Meta-analysis with publicly available databases is being carried out in order to obtain conclusive results of these findings. Importantly, we also observed statistical significance for six genomic AD signals (APOE-rs429358; BIN1-rs6733839 CD2AP-rs10948363, MS4A-rs983392, PICALM-rs10792832 and MAPT-rs2732703). Other 9 loci, described previously, had identical effect direction without significance due to the limited power to detect very small effects. GR@ACE is presented as a unique single-clinic GWAS for AD susceptibility with obvious advantages in terms of diagnosis homogeneity of patients and reduced stratification. Taking into account preliminary findings, the GR@ACE dataset can be considered a new genomic resource to research AD genomics. The resource is open to qualified researchers and ready for future international meta-analyses." @default.
- W2897092521 created "2018-10-26" @default.
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- W2897092521 date "2018-07-01" @default.
- W2897092521 modified "2023-10-17" @default.
- W2897092521 title "P2‐139: GENOME‐WIDE ASSOCIATION STUDY OF ALZHEIMER'S DISEASE (AD) SUSCEPTIBILITY USING THE FUNDACIO ACE GENOME REPOSITORY: THE GR@ACE PROJECT" @default.
- W2897092521 doi "https://doi.org/10.1016/j.jalz.2018.06.825" @default.
- W2897092521 hasPublicationYear "2018" @default.
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