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- W2897095417 abstract "The purpose of the present study is to access the linkage between dysregulation of glutamatergic neurotransmission, oxidative metabolism, and serine signaling in age-related cognitive decline. In this work, we evaluated the effect of natural aging in rats on the cognitive abilities for hippocampal-dependent tasks. Oxidative metabolism indicators are glutathione (GSH), malondialdehyde (MDA) concentrations, and cytosolic phospholipase A2 (PLA2) activity. In addition, neurotransmitter amino acid (L-Glutamic acid, γ-aminobutyric acid (GABA), DL-Serine and DL-Aspartic acid) concentrations were studied in brain areas such as the frontal cortex (FC) and hippocampus (HPC). The spatial long-term memory revealed significant differences among experimental groups: the aged rats showed an increase in escape latency to the platform associated with a reduction of crossings and spent less time on the target quadrant than young rats. Glutathione levels decreased for analyzed brain areas linked with a significant increase in MDA concentrations and PLA2 activity in cognitive-deficient old rats. We found glutamate levels only increased in the HPC, whereas a reduced level of serine was found in both regions of interest in cognitive-deficient old rats. We demonstrated that age-related changes in redox metabolism contributed with alterations in synaptic signaling and cognitive impairment." @default.
- W2897095417 created "2018-10-26" @default.
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- W2897095417 date "2018-10-13" @default.
- W2897095417 modified "2023-09-27" @default.
- W2897095417 title "Cellular Redox Imbalance and Neurochemical Effect in Cognitive-Deficient Old Rats" @default.
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- W2897095417 doi "https://doi.org/10.3390/bs8100093" @default.
- W2897095417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6211049" @default.
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