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- W2897096893 abstract "Fetal cerebellar hypoplasia and large cavum septi pellucidi (CSP) are often found in Trisomy 18 by prenatal ultrasound. The aim of this study was to explore the effectiveness of the index of fetal anteroposterior cerebella diameter and the width of cavum septi pellucidi ratio for diagnosis of Trisomy 18 during second and third trimester screening. This cross-sectional study included fetuses of Trisomy 18 confirmed by karyotype analysis from January 2004 to December 2017. Stored two-dimensional images or three-dimensional volumes of fetuses between 15 and 32 weeks' gestation from the first Affiliated Hospital Sun-Yat Sen University were analysed. The measurement of transverse cerebella diameter (TCD), anteroposterior cerebella diameter (APCD) and width of CSP was acquired in the trans-cerebellar axial plane. The ratio of APCD to CSP in this group was compared with groups and in hospital normal fetuses (gestational age, 15–35 weeks) and other aneuploidy fetuses (gestational age, 15–32weeks). Trisomy 18 group included 76 cases. Other aneuploidy group included 89 cases of Trisomy 21, 9 cases of Trisomy 13 and 2 cases of Turner syndrome. The normal group included 336 fetuses with no morphologic abnormalities. In normal group APCD/CSP were not correlated with GA (r2=0.09, P=0.09). The mean values of APCD/CSP in the normal group, Trisomy 18 group and other aneuploidy group were 3.136, 1.799 and 2.398, respectively. APCD/CSP was significantly different between group Trisomy 18 and the other two groups (P<0.0001). Area under curve was 94%. An ROC curve showed that APCD/CSP cut-off value at 2.182 exhibited an 80.3% sensitivity and 87.2% specificity. This study indicates that APCD/CSP may be used as a novel index for the prenatal detection of fetal Trisomy 18." @default.
- W2897096893 created "2018-10-26" @default.
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- W2897096893 date "2018-10-01" @default.
- W2897096893 modified "2023-10-14" @default.
- W2897096893 title "OC03.05: A novel index of fetal anteroposterior cerebella diameter and cavum septi pellucidi ratio for prenatal diagnosis of Trisomy 18" @default.
- W2897096893 doi "https://doi.org/10.1002/uog.19222" @default.
- W2897096893 hasPublicationYear "2018" @default.
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