Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897097268> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2897097268 endingPage "S105" @default.
- W2897097268 startingPage "S105" @default.
- W2897097268 abstract "Given the higher dose of radiation per fraction using stereotactic body radiation therapy (SBRT) there is concern about erectile function after prostate SBRT. This endpoint was measured in a prospective multi-institutional study of high-dose-rate brachytherapy-like (HDR-like) SBRT for prostate cancer. Between 2007 and 2012, 259 men with clinically localized prostate cancer were treated with SBRT monotherapy using a heterogeneous, HDR-like approach. Patients were treated with robotic SBRT to a total dose of 38 Gy in 4 fractions. Patients did not receive androgen deprivation therapy (ADT). Potency was defined as a score of 4 or 5 on question 8.a of the patient-reported quality of life (PR-QOL) survey EPIC-26. In addition, the Sexual Health Inventory for Men (SHIM) was collected. PR-QOL was assessed at baseline and 6, 12, 24, 36, 48, and 60 months after treatment. Erectile function was correlated with multiple patient and dosimetric variables. There were 107 men potent at baseline, including 46 low- and 61 intermediate-risk patients, with a median age of 65 years (range, 45-80 years). The proportion of patients reporting potency decreased with time post-treatment. The median time post-treatment to the first report of “non-potent” was 12 months. The 24- and 60-month proportion potent was 43% and 36%, respectively. None of the dosimetric variables (dose to prostate, penile bulb, and neurovascular bundles) were found to correlate with potency at any time point. Likewise, neither baseline testosterone levels nor age at treatment predicted potency. Baseline SHIM score was correlated with higher potency rates at 6 and 60 months post-treatment (median baseline SHIM 21.6 for potent versus 16.2 for not potent at 60 months, p=0.004). Smaller prostate volume was correlated with a higher potency rate at 60 months (median prostate volume 33.8 cc for potent versus 46.1 cc for not potent at 60 months, P=0.008). Only higher baseline sexual QOL and a smaller pre-SBRT prostate volume were correlated with improved long-term post-treatment erectile function post-SBRT, while no other prostate, penile bulb or neurovascular bundle dosimetry variable had any significant measurable potency outcome correlation. This suggests that “patient factors” are more significant than dosimetry factors in predicting sexual QOL domain outcome post-SBRT." @default.
- W2897097268 created "2018-10-26" @default.
- W2897097268 creator A5001135125 @default.
- W2897097268 creator A5026731460 @default.
- W2897097268 creator A5033886756 @default.
- W2897097268 creator A5053897830 @default.
- W2897097268 creator A5063248924 @default.
- W2897097268 creator A5084208992 @default.
- W2897097268 date "2018-11-01" @default.
- W2897097268 modified "2023-10-18" @default.
- W2897097268 title "Erectile Function after High-Dose-Rate Brachytherapy-like Stereotactic Body Radiation Therapy for Organ-Confined Prostate Cancer" @default.
- W2897097268 doi "https://doi.org/10.1016/j.ijrobp.2018.06.268" @default.
- W2897097268 hasPublicationYear "2018" @default.
- W2897097268 type Work @default.
- W2897097268 sameAs 2897097268 @default.
- W2897097268 citedByCount "0" @default.
- W2897097268 crossrefType "journal-article" @default.
- W2897097268 hasAuthorship W2897097268A5001135125 @default.
- W2897097268 hasAuthorship W2897097268A5026731460 @default.
- W2897097268 hasAuthorship W2897097268A5033886756 @default.
- W2897097268 hasAuthorship W2897097268A5053897830 @default.
- W2897097268 hasAuthorship W2897097268A5063248924 @default.
- W2897097268 hasAuthorship W2897097268A5084208992 @default.
- W2897097268 hasConcept C105572291 @default.
- W2897097268 hasConcept C121608353 @default.
- W2897097268 hasConcept C126322002 @default.
- W2897097268 hasConcept C126894567 @default.
- W2897097268 hasConcept C141071460 @default.
- W2897097268 hasConcept C185592680 @default.
- W2897097268 hasConcept C188816634 @default.
- W2897097268 hasConcept C202751555 @default.
- W2897097268 hasConcept C2775871022 @default.
- W2897097268 hasConcept C2776235491 @default.
- W2897097268 hasConcept C2776651944 @default.
- W2897097268 hasConcept C2777416452 @default.
- W2897097268 hasConcept C2777899217 @default.
- W2897097268 hasConcept C2779929075 @default.
- W2897097268 hasConcept C2780192828 @default.
- W2897097268 hasConcept C2780387249 @default.
- W2897097268 hasConcept C2780493668 @default.
- W2897097268 hasConcept C2989005 @default.
- W2897097268 hasConcept C509974204 @default.
- W2897097268 hasConcept C55493867 @default.
- W2897097268 hasConcept C57992300 @default.
- W2897097268 hasConcept C71924100 @default.
- W2897097268 hasConceptScore W2897097268C105572291 @default.
- W2897097268 hasConceptScore W2897097268C121608353 @default.
- W2897097268 hasConceptScore W2897097268C126322002 @default.
- W2897097268 hasConceptScore W2897097268C126894567 @default.
- W2897097268 hasConceptScore W2897097268C141071460 @default.
- W2897097268 hasConceptScore W2897097268C185592680 @default.
- W2897097268 hasConceptScore W2897097268C188816634 @default.
- W2897097268 hasConceptScore W2897097268C202751555 @default.
- W2897097268 hasConceptScore W2897097268C2775871022 @default.
- W2897097268 hasConceptScore W2897097268C2776235491 @default.
- W2897097268 hasConceptScore W2897097268C2776651944 @default.
- W2897097268 hasConceptScore W2897097268C2777416452 @default.
- W2897097268 hasConceptScore W2897097268C2777899217 @default.
- W2897097268 hasConceptScore W2897097268C2779929075 @default.
- W2897097268 hasConceptScore W2897097268C2780192828 @default.
- W2897097268 hasConceptScore W2897097268C2780387249 @default.
- W2897097268 hasConceptScore W2897097268C2780493668 @default.
- W2897097268 hasConceptScore W2897097268C2989005 @default.
- W2897097268 hasConceptScore W2897097268C509974204 @default.
- W2897097268 hasConceptScore W2897097268C55493867 @default.
- W2897097268 hasConceptScore W2897097268C57992300 @default.
- W2897097268 hasConceptScore W2897097268C71924100 @default.
- W2897097268 hasIssue "3" @default.
- W2897097268 hasLocation W28970972681 @default.
- W2897097268 hasOpenAccess W2897097268 @default.
- W2897097268 hasPrimaryLocation W28970972681 @default.
- W2897097268 hasRelatedWork W1905464153 @default.
- W2897097268 hasRelatedWork W1919251957 @default.
- W2897097268 hasRelatedWork W1941422729 @default.
- W2897097268 hasRelatedWork W2069358229 @default.
- W2897097268 hasRelatedWork W2079497195 @default.
- W2897097268 hasRelatedWork W2084448725 @default.
- W2897097268 hasRelatedWork W2085529113 @default.
- W2897097268 hasRelatedWork W2757672296 @default.
- W2897097268 hasRelatedWork W4224285726 @default.
- W2897097268 hasRelatedWork W4250175054 @default.
- W2897097268 hasVolume "102" @default.
- W2897097268 isParatext "false" @default.
- W2897097268 isRetracted "false" @default.
- W2897097268 magId "2897097268" @default.
- W2897097268 workType "article" @default.