FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897097274> ?p ?o ?g. }

• W2897097274 endingPage "212" @default.
• W2897097274 startingPage "204" @default.
• W2897097274 abstract "Abstract The molecular complexity of triple-negative breast cancers (TNBCs) provides a challenge for patient management. We set out to characterize this heterogeneous disease by combining transcriptomics and genomics data, with the aim of revealing convergent pathway dependencies with the potential for treatment intervention. A Bayesian algorithm was used to integrate molecular profiles in two TNBC cohorts, followed by validation using five independent cohorts (n = 1,168), including three clinical trials. A four-gene decision tree signature was identified, which robustly classified TNBCs into six subtypes. All four genes in the signature (EXO1, TP53BP2, FOXM1, and RSU1) are associated with either genomic instability, malignant growth, or treatment response. One of the six subtypes, MC6, encompassed the largest proportion of tumors (∼50%) in early diagnosed TNBCs. In TNBC patients with metastatic disease, the MC6 proportion was reduced to 25%, and was independently associated with a higher response rate to platinum-based chemotherapy. In TNBC cell line data, platinum sensitivity was recapitulated, and a sensitivity to the inhibition of the phosphatase PPM1D was revealed. Molecularly, MC6-TNBCs displayed high levels of telomeric allelic imbalances, enrichment of CD4+ and CD8+ immune signatures, and reduced expression of genes negatively regulating the MAPK signaling pathway. These observations suggest that our integrative classification approach may identify TNBC patients with discernible and theoretically pharmacologically tractable features that merit further studies in prospective trials." @default.
• W2897097274 created "2018-10-26" @default.
• W2897097274 creator A5015356443 @default.
• W2897097274 creator A5019349196 @default.
• W2897097274 creator A5040450413 @default.
• W2897097274 creator A5048636641 @default.
• W2897097274 creator A5052487618 @default.
• W2897097274 creator A5054103832 @default.
• W2897097274 creator A5071432873 @default.
• W2897097274 creator A5087121536 @default.
• W2897097274 date "2019-01-01" @default.
• W2897097274 modified "2023-09-30" @default.
• W2897097274 title "A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics" @default.
• W2897097274 cites W111284505 @default.
• W2897097274 cites W1872860230 @default.
• W2897097274 cites W1968667083 @default.
• W2897097274 cites W1979662083 @default.
• W2897097274 cites W1992906847 @default.
• W2897097274 cites W2002246796 @default.
• W2897097274 cites W2005895632 @default.
• W2897097274 cites W2006288875 @default.
• W2897097274 cites W2013168248 @default.
• W2897097274 cites W2030566540 @default.
• W2897097274 cites W2037900813 @default.
• W2897097274 cites W2044702943 @default.
• W2897097274 cites W2048245178 @default.
• W2897097274 cites W2063382533 @default.
• W2897097274 cites W2063432148 @default.
• W2897097274 cites W2064215138 @default.
• W2897097274 cites W2065141457 @default.
• W2897097274 cites W2074952360 @default.
• W2897097274 cites W2086064725 @default.
• W2897097274 cites W2096055355 @default.
• W2897097274 cites W2096145980 @default.
• W2897097274 cites W2096283457 @default.
• W2897097274 cites W2097255042 @default.
• W2897097274 cites W2105265201 @default.
• W2897097274 cites W2105496345 @default.
• W2897097274 cites W2108068107 @default.
• W2897097274 cites W2109972881 @default.
• W2897097274 cites W2110017381 @default.
• W2897097274 cites W2111429259 @default.
• W2897097274 cites W2116634113 @default.
• W2897097274 cites W2130410032 @default.
• W2897097274 cites W2131994307 @default.
• W2897097274 cites W2132619562 @default.
• W2897097274 cites W2134133462 @default.
• W2897097274 cites W2134539328 @default.
• W2897097274 cites W2142486051 @default.
• W2897097274 cites W2149681218 @default.
• W2897097274 cites W2152061559 @default.
• W2897097274 cites W2153206149 @default.
• W2897097274 cites W2161382947 @default.
• W2897097274 cites W2167105148 @default.
• W2897097274 cites W2168409298 @default.
• W2897097274 cites W2169016078 @default.
• W2897097274 cites W2259802687 @default.
• W2897097274 cites W2281388288 @default.
• W2897097274 cites W2306567488 @default.
• W2897097274 cites W2344657883 @default.
• W2897097274 cites W2345415641 @default.
• W2897097274 cites W2402636472 @default.
• W2897097274 cites W2430731787 @default.
• W2897097274 cites W2536094308 @default.
• W2897097274 cites W2560367415 @default.
• W2897097274 cites W2577194681 @default.
• W2897097274 cites W2596164112 @default.
• W2897097274 cites W2599454152 @default.
• W2897097274 cites W2611661848 @default.
• W2897097274 cites W2801956643 @default.
• W2897097274 cites W3093265161 @default.
• W2897097274 doi "https://doi.org/10.1158/1535-7163.mct-18-0243" @default.
• W2897097274 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6330084" @default.
• W2897097274 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30305342" @default.
• W2897097274 hasPublicationYear "2019" @default.
• W2897097274 type Work @default.
• W2897097274 sameAs 2897097274 @default.
• W2897097274 citedByCount "14" @default.
• W2897097274 countsByYear W28970972742019 @default.
• W2897097274 countsByYear W28970972742020 @default.
• W2897097274 countsByYear W28970972742021 @default.
• W2897097274 countsByYear W28970972742022 @default.
• W2897097274 countsByYear W28970972742023 @default.
• W2897097274 crossrefType "journal-article" @default.
• W2897097274 hasAuthorship W2897097274A5015356443 @default.
• W2897097274 hasAuthorship W2897097274A5019349196 @default.
• W2897097274 hasAuthorship W2897097274A5040450413 @default.
• W2897097274 hasAuthorship W2897097274A5048636641 @default.
• W2897097274 hasAuthorship W2897097274A5052487618 @default.
• W2897097274 hasAuthorship W2897097274A5054103832 @default.
• W2897097274 hasAuthorship W2897097274A5071432873 @default.
• W2897097274 hasAuthorship W2897097274A5087121536 @default.
• W2897097274 hasBestOaLocation W28970972741 @default.
• W2897097274 hasConcept C104317684 @default.
• W2897097274 hasConcept C121608353 @default.
• W2897097274 hasConcept C143998085 @default.
• W2897097274 hasConcept C150194340 @default.
• W2897097274 hasConcept C18431079 @default.

• next