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- W2897099387 endingPage "2018" @default.
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- W2897099387 abstract "ABSTRACT Introduction Hyperuricemia has been identified as an independent risk factor for coronary artery disease (CAD). Uric acid lowering therapy could potentially lower the risk of CAD. Conventional treatments have been effective in treating acute gout flares in most patients, but certain options, like NSAIDs could increase the risk of CAD. Area covered This review covers the aspect of cardiac safety with traditional and new medications used in treating both acute flares and chronic gout according to the most recent international guidelines. Expert opinion All NSAIDs, not just selective Cox 2 inhibitors, have associated with them different degrees of cardiac risk; therefore, NSAIDs should be avoided when treating patients with underlying CAD. Interleukin-1 inhibitors appear to be safe alternatives for treating cardiac patients who are contraindicated to conventional treatment. Presently, there is a paucity of evidence concerning whether treatment of hyperuricemia could lower the risk of CAD and this must be explored further. It is also important to explore the cardiac safety of plegloticase to better ascertain its safety in CAD patients." @default.
- W2897099387 created "2018-10-26" @default.
- W2897099387 creator A5029045596 @default.
- W2897099387 creator A5056184727 @default.
- W2897099387 date "2018-10-20" @default.
- W2897099387 modified "2023-09-27" @default.
- W2897099387 title "Pharmacotherapeutic management of gout in patients with cardiac disease" @default.
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- W2897099387 doi "https://doi.org/10.1080/14656566.2018.1536747" @default.
- W2897099387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30345832" @default.
- W2897099387 hasPublicationYear "2018" @default.
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