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• W2897112063 abstract "Aim: The mitotic spindle plays a key role in cell division which makes it an important target in cancer therapy. In the present study the antiproliferative activity of 4-benzyl-5-phenyl-3,4-dihydropyrimidine-2(1H)-thione (1) and its pyridine bioisoster (2) were evaluated and compared with monastrol (MON), the first known cell-permeable small molecule which disrupts bipolar spindle formation by inhibiting Eg5-kinesin activity. Results: Our data revealed that compound 2 showed higher antiproliferative activity than MON against MCF7 and A375 cell lines and comparable reversible cell cycle inhibition in G2/M phase. However, compound 2 produced distinct phenotype from monoastral spindles, and did not affect Eg5 ATPase activity. Conclusion: The activity of compound 2 may suggest its new promising anticancer mechanism (different than MON), targeting other component required for spindle bipolarity." @default.
• W2897112063 created "2018-10-26" @default.
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• W2897112063 date "2018-10-01" @default.
• W2897112063 modified "2023-09-27" @default.
• W2897112063 title "Comparative evaluation of new dihydropyrimidine and dihydropyridine derivatives perturbing mitotic spindle formation" @default.
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• W2897112063 doi "https://doi.org/10.4155/fmc-2018-0094" @default.
• W2897112063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30325216" @default.
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