Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897112484> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2897112484 abstract "High sodium diet (HSD) is a risk factor for stroke and dementia independent of hypertension, but it remains unclear if dietary salt impairs cognition. To address this question, we fed HSD (8% NaCl) or normal diet (ND; 0.5% NaCl) to males C57BL/6 mice for 12 weeks (n=10/group) and assessed cognitive function. At a novel object recognition task (non-spatial memory) HSD mice failed to identify a new object from a familiar one (ND: 72.4±2%, HSD: 56.4±2%, p<0.05). At the Barnes maze test, HSD mice took longer to locate the escape hole (ND: 26±5sec, HSD: 64±12sec, p<0.05), suggesting impaired spatial memory. Nesting behavior, akin to activities of daily living in humans, was also impaired (ND: 4.6±0.1, HSD: 4.1±0.1, Deacon scale, p<0.05). Since HSD alters endothelial function (Compr Physiol, 6:215, 2015) and endothelial nitric oxide (NO) plays a role in cognition (J Neurosc, 26:11513, 2006), we assessed NO production in isolated brain microvessels using DAF-FM as a marker. In HSD mice, NO levels were markedly reduced (ND: 0.33±0.04, HSD: 0.19±0.02 RFU/μm2, p<0.05) and the NO increase produced by the endothelium-dependent agonist acetylcholine (ACh) was suppressed (ND, Veh: 0.33±0.04, ACh: 0.54±0.05 RFU, p<0.05; HSD, Veh: 0.19±0.02, ACh: 0.25±0.05 RFU/μm2, p>0.05). Endothelial NO participates in synaptic plasticity by contributing to maintain normal levels of the neurotrophic factor BDNF (Eur J Neurosc, 44:2226, 2016). Hippocampal BDNF levels were reduced in HSD mice (-52±3%, p<0.05). Consistent with attenuated BDNF signaling, we also observed reductions in the phosphorylation of the BDNF receptor TrkB (-31±0.1%), and of related signaling molecules (ERK1/2: -36±1%; CREB: -45±1%; p<0.05). Arc, a protein involved in memory formation and dependent on BDNF, was also reduced (-41±1%; p<0.05). The data suggest that HSD-induced endothelial dysfunction leads to reduced NO, which, in turn, suppresses hippocampal BDNF and attendant signaling pathways, resulting in impaired synaptic plasticity and cognitive deficits. The finding that dietary salt has a profound impact of on cognition highlights the harmful effects of endothelial dysfunction on brain health and supports public health efforts to curb salt intake especially in individuals at high vascular risk." @default.
- W2897112484 created "2018-10-26" @default.
- W2897112484 creator A5002902942 @default.
- W2897112484 creator A5023761982 @default.
- W2897112484 creator A5030829514 @default.
- W2897112484 creator A5030921116 @default.
- W2897112484 creator A5043738552 @default.
- W2897112484 creator A5058899441 @default.
- W2897112484 creator A5088750311 @default.
- W2897112484 date "2018-01-22" @default.
- W2897112484 modified "2023-10-05" @default.
- W2897112484 title "Abstract TMP94: Dietary Salt Impairs Cognitive Function Through Suppression of Endothelial Nitric Oxide Synthesis and Hippocampal BDNF Signaling" @default.
- W2897112484 doi "https://doi.org/10.1161/str.49.suppl_1.tmp94" @default.
- W2897112484 hasPublicationYear "2018" @default.
- W2897112484 type Work @default.
- W2897112484 sameAs 2897112484 @default.
- W2897112484 citedByCount "0" @default.
- W2897112484 crossrefType "journal-article" @default.
- W2897112484 hasAuthorship W2897112484A5002902942 @default.
- W2897112484 hasAuthorship W2897112484A5023761982 @default.
- W2897112484 hasAuthorship W2897112484A5030829514 @default.
- W2897112484 hasAuthorship W2897112484A5030921116 @default.
- W2897112484 hasAuthorship W2897112484A5043738552 @default.
- W2897112484 hasAuthorship W2897112484A5058899441 @default.
- W2897112484 hasAuthorship W2897112484A5088750311 @default.
- W2897112484 hasConcept C118552586 @default.
- W2897112484 hasConcept C126322002 @default.
- W2897112484 hasConcept C134018914 @default.
- W2897112484 hasConcept C148762608 @default.
- W2897112484 hasConcept C169760540 @default.
- W2897112484 hasConcept C169900460 @default.
- W2897112484 hasConcept C2776992346 @default.
- W2897112484 hasConcept C2780972559 @default.
- W2897112484 hasConcept C519581460 @default.
- W2897112484 hasConcept C71924100 @default.
- W2897112484 hasConcept C86803240 @default.
- W2897112484 hasConceptScore W2897112484C118552586 @default.
- W2897112484 hasConceptScore W2897112484C126322002 @default.
- W2897112484 hasConceptScore W2897112484C134018914 @default.
- W2897112484 hasConceptScore W2897112484C148762608 @default.
- W2897112484 hasConceptScore W2897112484C169760540 @default.
- W2897112484 hasConceptScore W2897112484C169900460 @default.
- W2897112484 hasConceptScore W2897112484C2776992346 @default.
- W2897112484 hasConceptScore W2897112484C2780972559 @default.
- W2897112484 hasConceptScore W2897112484C519581460 @default.
- W2897112484 hasConceptScore W2897112484C71924100 @default.
- W2897112484 hasConceptScore W2897112484C86803240 @default.
- W2897112484 hasIssue "Suppl_1" @default.
- W2897112484 hasLocation W28971124841 @default.
- W2897112484 hasOpenAccess W2897112484 @default.
- W2897112484 hasPrimaryLocation W28971124841 @default.
- W2897112484 hasRelatedWork W1607056059 @default.
- W2897112484 hasRelatedWork W2009632099 @default.
- W2897112484 hasRelatedWork W2031141543 @default.
- W2897112484 hasRelatedWork W2057108179 @default.
- W2897112484 hasRelatedWork W2060234257 @default.
- W2897112484 hasRelatedWork W2086224793 @default.
- W2897112484 hasRelatedWork W2782500236 @default.
- W2897112484 hasRelatedWork W2891987111 @default.
- W2897112484 hasRelatedWork W2892205440 @default.
- W2897112484 hasRelatedWork W2914868351 @default.
- W2897112484 hasRelatedWork W2926365437 @default.
- W2897112484 hasRelatedWork W2961894100 @default.
- W2897112484 hasRelatedWork W3042387270 @default.
- W2897112484 hasRelatedWork W3045723046 @default.
- W2897112484 hasRelatedWork W3046108304 @default.
- W2897112484 hasRelatedWork W3124244829 @default.
- W2897112484 hasRelatedWork W3137405717 @default.
- W2897112484 hasRelatedWork W3163087701 @default.
- W2897112484 hasRelatedWork W3203652102 @default.
- W2897112484 hasRelatedWork W3210024993 @default.
- W2897112484 hasVolume "49" @default.
- W2897112484 isParatext "false" @default.
- W2897112484 isRetracted "false" @default.
- W2897112484 magId "2897112484" @default.
- W2897112484 workType "article" @default.