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- W2897133090 abstract "Vascular cognitive impairment (VCI), defined as a decline in cognition resulting from stroke or subclinical vascular brain injury, is one of the leading causes of cognitive impairment and dementia worldwide. Currently, beyond rapid-response treatments to resolve the vascular lesion, effective therapies to protect or restore cognitive function are lacking. Motivated by this need, we sought to identify a novel mechanism differentially expressed in cases of VCI compared to incidences of Alzheimer's disease (AD) and no dementia. We used Agilent microarray technology to quantify gene expression in frozen frontal cortex tissue obtained postmortem from University of Michigan AD Center subjects who died with VCI (of the multi-infarct subtype), moderate AD, or without dementia. qPCR and western blotting were used to validate microarray results. Immunohistochemistry was also performed using paraffin embedded frontal cortex tissue from the same cases. We identified a previously unreported upregulation of the oxytocin receptor (OXTR) in the frontal cortex of VCI subjects compared to AD and no dementia controls (log fold change = 1.86, FDR adjusted p < 0.04). OXTR upregulation in VCI was confirmed via qPCR (one-way ANOVA [F=3.886, p=0.0329]) and western blotting (Kruskal-Wallis [χ2=7.07, p=0.0292]). Immunohistochemical analysis revealed widespread OXTR expression in frontal cortex, with notable co-localization of the receptor with tomato lectin, a vascular endothelial cell marker. Given the established role of oxytocin in anti-inflammatory, antioxidant, and angiogenic signaling, we posit that OXTR upregulation in VCI is indicative of a vascular localized compensatory response that could be harnessed therapeutically to ameliorate the pathologic aspects of ischemic or hemorrhagic injury, promote cell survival, and improve cognitive outcomes. We are testing this hypothesis mechanistically in a novel rodent model of VCI and in vascular cell cultures subjected to hypoxia." @default.
- W2897133090 created "2018-10-26" @default.
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- W2897133090 date "2018-07-01" @default.
- W2897133090 modified "2023-10-16" @default.
- W2897133090 title "P3‐208: THE OXYTOCIN RECEPTOR AND VASCULAR COGNITIVE IMPAIRMENT: POTENTIAL AS A NOVEL THERAPEUTIC TARGET" @default.
- W2897133090 doi "https://doi.org/10.1016/j.jalz.2018.06.1567" @default.
- W2897133090 hasPublicationYear "2018" @default.
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