FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897139310> ?p ?o ?g. }

• W2897139310 abstract "The 5′ ends of most RNAs are chemically modified to enable protection from nucleases. In bacteria, this is often achieved by keeping the triphosphate terminus originating from transcriptional initiation, while most eukaryotic mRNAs and small nuclear RNAs have a 5′→5′ linked N 7 ‐methyl guanosine (m 7 G) cap added. Several other chemical modifications have been described at RNA 5′ ends. Common to all modifications is the presence of at least one pyrophosphate bond. To enable RNA turnover, these chemical modifications at the RNA 5′ end need to be reversible. Dependent on the direction of the RNA decay pathway (5′→3′ or 3′→5′), some enzymes cleave the 5′→5′ cap linkage of intact RNAs to initiate decay, while others act as scavengers and hydrolyse the cap element of the remnants of the 3′→5′ decay pathway. In eukaryotes, there is also a cap quality control pathway. Most enzymes involved in the cleavage of the RNA 5′ ends are pyrophosphohydrolases, with only a few having (additional) 5′ triphosphonucleotide hydrolase activities. Despite the identity of their enzyme activities, the enzymes belong to four different enzyme classes. Nudix hydrolases decap intact RNAs as part of the 5′→3′ decay pathway, DXO family members mainly degrade faulty RNAs, members of the histidine triad (HIT) family are scavenger proteins, while an ApaH‐like phosphatase is the major mRNA decay enzyme of trypanosomes, whose RNAs have a unique cap structure. Many novel cap structures and decapping enzymes have only recently been discovered, indicating that we are only beginning to understand the mechanisms of RNA decapping. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability RNA Processing > Capping and 5′ End Modifications" @default.
• W2897139310 created "2018-10-26" @default.
• W2897139310 creator A5084431379 @default.
• W2897139310 creator A5091728303 @default.
• W2897139310 date "2018-10-21" @default.
• W2897139310 modified "2023-10-09" @default.
• W2897139310 title "The complex enzymology of mRNA decapping: Enzymes of four classes cleave pyrophosphate bonds" @default.
• W2897139310 cites W1061309758 @default.
• W2897139310 cites W1494438241 @default.
• W2897139310 cites W1502618518 @default.
• W2897139310 cites W1506014073 @default.
• W2897139310 cites W1506886301 @default.
• W2897139310 cites W1513015502 @default.
• W2897139310 cites W1584817945 @default.
• W2897139310 cites W1786582555 @default.
• W2897139310 cites W181468314 @default.
• W2897139310 cites W1966761578 @default.
• W2897139310 cites W1967356824 @default.
• W2897139310 cites W1968548446 @default.
• W2897139310 cites W1970367879 @default.
• W2897139310 cites W1971421846 @default.
• W2897139310 cites W1971529523 @default.
• W2897139310 cites W1972232080 @default.
• W2897139310 cites W1973523725 @default.
• W2897139310 cites W1977672277 @default.
• W2897139310 cites W1978193049 @default.
• W2897139310 cites W1978560967 @default.
• W2897139310 cites W1981550130 @default.
• W2897139310 cites W1985114988 @default.
• W2897139310 cites W1986813053 @default.
• W2897139310 cites W1988130645 @default.
• W2897139310 cites W1989099938 @default.
• W2897139310 cites W1989951007 @default.
• W2897139310 cites W1992246409 @default.
• W2897139310 cites W1994146567 @default.
• W2897139310 cites W1995816032 @default.
• W2897139310 cites W1997952030 @default.
• W2897139310 cites W1998929627 @default.
• W2897139310 cites W2001197674 @default.
• W2897139310 cites W2003818671 @default.
• W2897139310 cites W2005024648 @default.
• W2897139310 cites W2005642753 @default.
• W2897139310 cites W2006415216 @default.
• W2897139310 cites W2007930204 @default.
• W2897139310 cites W2009047404 @default.
• W2897139310 cites W2009203565 @default.
• W2897139310 cites W2009315890 @default.
• W2897139310 cites W2010864006 @default.
• W2897139310 cites W2012949590 @default.
• W2897139310 cites W2013023817 @default.
• W2897139310 cites W2019832665 @default.
• W2897139310 cites W2020376695 @default.
• W2897139310 cites W2023118737 @default.
• W2897139310 cites W2025473874 @default.
• W2897139310 cites W2026724911 @default.
• W2897139310 cites W2026851346 @default.
• W2897139310 cites W2028223218 @default.
• W2897139310 cites W2030835578 @default.
• W2897139310 cites W2031345354 @default.
• W2897139310 cites W2038735956 @default.
• W2897139310 cites W2039209606 @default.
• W2897139310 cites W2043146404 @default.
• W2897139310 cites W2045281368 @default.
• W2897139310 cites W2045365169 @default.
• W2897139310 cites W2046019269 @default.
• W2897139310 cites W2047008303 @default.
• W2897139310 cites W2047479529 @default.
• W2897139310 cites W2050843600 @default.
• W2897139310 cites W2053653446 @default.
• W2897139310 cites W2056015083 @default.
• W2897139310 cites W2057862944 @default.
• W2897139310 cites W2057997270 @default.
• W2897139310 cites W2059993444 @default.
• W2897139310 cites W2060678979 @default.
• W2897139310 cites W2062019035 @default.
• W2897139310 cites W2064433587 @default.
• W2897139310 cites W2065104935 @default.
• W2897139310 cites W2067487818 @default.
• W2897139310 cites W2068311929 @default.
• W2897139310 cites W2068778722 @default.
• W2897139310 cites W2073302338 @default.
• W2897139310 cites W2073921237 @default.
• W2897139310 cites W2074062134 @default.
• W2897139310 cites W2074194066 @default.
• W2897139310 cites W2075181140 @default.
• W2897139310 cites W2075577819 @default.
• W2897139310 cites W2077034092 @default.
• W2897139310 cites W2077936726 @default.
• W2897139310 cites W2080902551 @default.
• W2897139310 cites W2082514511 @default.
• W2897139310 cites W2082544879 @default.
• W2897139310 cites W2086106383 @default.
• W2897139310 cites W2088860412 @default.
• W2897139310 cites W2092455508 @default.
• W2897139310 cites W2093085392 @default.
• W2897139310 cites W2095058079 @default.
• W2897139310 cites W2095842290 @default.
• W2897139310 cites W2097847233 @default.
• W2897139310 cites W2099400747 @default.
• W2897139310 cites W2101524123 @default.

• next