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• W2897158575 abstract "Abstract Aim Alpha‐lipoic acid (ALA) is a short chain fatty acid which has a key role in energy production. ALA is also known as a universal antioxidant. The aim of the present study was to explore the effects of ALA supplementation in women with gestational diabetes mellitus. Methods A randomized double‐blind placebo‐controlled clinical trial study was designed. Women with gestational diabetes mellitus ( n = 60) during 24–28 weeks of gestation were selected and divided randomly into drug ( n = 30) and placebo ( n = 30) groups. Drug group supplemented with ALA (100 mg/day) for 8 weeks. The biochemical markers were measured before and after the intervention and considered significant at a P ‐value less than 0.05. Results Maternal circulating values of fasting blood sugar ( P < 0.001), gamma‐glutamyltransferase ( P < 0.001) and alanine transaminase ( P = 0.031) were decreased in the drug group after the intervention. However, values of urea, creatinine, uric acid, aspartate transaminase and alkaline phosphatase were not changed significantly after the trial. Conclusion The present study has shown that supplementation with 100 mg/day of ALA had some beneficial effects on glucose metabolism and liver function in women with gestational diabetes mellitus." @default.
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• W2897158575 date "2018-10-16" @default.
• W2897158575 modified "2023-09-27" @default.
• W2897158575 title "Reduction in maternal serum values of glucose and gamma-glutamyltransferase after supplementation with alpha-lipoic acid in women with gestational diabetes mellitus" @default.
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• W2897158575 doi "https://doi.org/10.1111/jog.13842" @default.
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