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- W2897185627 abstract "Flap structure-specific endonuclease 1 (FEN1) is overexpressed in various types of human cancer cells and has been recognized as a promising biomarker for cancer diagnosis in the recent years. In order to specifically detect the abundance and activity of this cancer-overexpressed enzyme, different types of DNA-based nanodevices were created during our investigations. It is shown in our studies that these newly designed biosensors are highly sensitive and specific for FEN1 in living cells as well as in cell-free systems. It is expected that these nanoprobes could be useful for monitoring FEN1 activity in human cancer cells, and also for cell-based screening of FEN1 inhibitors as new anticancer drugs." @default.
- W2897185627 created "2018-10-26" @default.
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- W2897185627 date "2018-10-17" @default.
- W2897185627 modified "2023-10-15" @default.
- W2897185627 title "Versatile Types of DNA-Based Nanobiosensors for Specific Detection of Cancer Biomarker FEN1 in Living Cells and Cell-Free Systems" @default.
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- W2897185627 doi "https://doi.org/10.1021/acs.nanolett.8b03724" @default.
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