FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897187561> ?p ?o ?g. }

• W2897187561 abstract "New regimens involving direct-acting antiviral agents (DAAs) have recently been approved for the treatment of hepatitis C virus (HCV) genotype 4 (GT4). The current study aims to assess the efficacy and safety of sofosbuvir (SOF) with pegylated interferon (PegINF)/ribavirin (RBV) for chronic HCV GT4 patients at the beginning of the interferon-free era.Between March 2015 and November 2015, 99 patients (59 naïve and 40 experienced) infected with HCV GT4 were enrolled in the study. Eligible patients received daily oral 400 mg SOF, RBV (body weight: < 75 kg, 1000 mg; < 75 kg, 1200 mg), the dose modified according to patient tolerability, plus 180 μg PegINFα-2 once weekly for 12 weeks.Among the patient cohort, sustained virological response 12 weeks after the end of treatment (SVR12) was achieved by 88% (87/99) of all patients, by 93% (55/59) of naïve patients and by 80% (32/40) of experienced patients. Regarding treatment failure, the data recorded 12% (12/99) of patients (4 null responses and 8 relapsers). Otherwise, the most common adverse events observed during the study included headache, nausea, fatigue, dyspnea, influenza-like illness, anemia, and leukopenia.SOF combination-based therapies were considered promising choice regimens for chronic HCV infection. The present findings suggest that the combination of the SOF/PegINF/RBV regimen was effective for Egyptian patients with HCV GT4. The recorded adverse events and viral outcome revealed the high need for further efforts to minimize the side effects of the current regimen and/or replace PegINF with additional potent DAA(s) to increase SVR12 to achieve 100%." @default.
• W2897187561 created "2018-10-26" @default.
• W2897187561 creator A5015288283 @default.
• W2897187561 creator A5022417455 @default.
• W2897187561 creator A5037000690 @default.
• W2897187561 creator A5086747118 @default.
• W2897187561 creator A5091366155 @default.
• W2897187561 date "2018-01-01" @default.
• W2897187561 modified "2023-09-26" @default.
• W2897187561 title "Effectiveness of sofosbuvir/pegylated-interferon plus ribavirin in treatment of hepatitis C virus genotype 4 patients" @default.
• W2897187561 cites W1981346902 @default.
• W2897187561 cites W2000043675 @default.
• W2897187561 cites W2007852355 @default.
• W2897187561 cites W2030969088 @default.
• W2897187561 cites W2037648619 @default.
• W2897187561 cites W2063049747 @default.
• W2897187561 cites W2064387090 @default.
• W2897187561 cites W2078251659 @default.
• W2897187561 cites W2116047701 @default.
• W2897187561 cites W2117115804 @default.
• W2897187561 cites W2120733999 @default.
• W2897187561 cites W2131494527 @default.
• W2897187561 cites W2133647046 @default.
• W2897187561 cites W2136218615 @default.
• W2897187561 cites W2175038046 @default.
• W2897187561 cites W2292568431 @default.
• W2897187561 cites W2565410143 @default.
• W2897187561 cites W2569547219 @default.
• W2897187561 doi "https://doi.org/10.5114/ceh.2018.78123" @default.
• W2897187561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6185926" @default.
• W2897187561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30324144" @default.
• W2897187561 hasPublicationYear "2018" @default.
• W2897187561 type Work @default.
• W2897187561 sameAs 2897187561 @default.
• W2897187561 citedByCount "3" @default.
• W2897187561 countsByYear W28971875612019 @default.
• W2897187561 countsByYear W28971875612020 @default.
• W2897187561 crossrefType "journal-article" @default.
• W2897187561 hasAuthorship W2897187561A5015288283 @default.
• W2897187561 hasAuthorship W2897187561A5022417455 @default.
• W2897187561 hasAuthorship W2897187561A5037000690 @default.
• W2897187561 hasAuthorship W2897187561A5086747118 @default.
• W2897187561 hasAuthorship W2897187561A5091366155 @default.
• W2897187561 hasBestOaLocation W28971875611 @default.
• W2897187561 hasConcept C126322002 @default.
• W2897187561 hasConcept C142462285 @default.
• W2897187561 hasConcept C197934379 @default.
• W2897187561 hasConcept C203014093 @default.
• W2897187561 hasConcept C2522874641 @default.
• W2897187561 hasConcept C2776408679 @default.
• W2897187561 hasConcept C2776455275 @default.
• W2897187561 hasConcept C2776461080 @default.
• W2897187561 hasConcept C2776694085 @default.
• W2897187561 hasConcept C2778375690 @default.
• W2897187561 hasConcept C2778390639 @default.
• W2897187561 hasConcept C2779298103 @default.
• W2897187561 hasConcept C2780040827 @default.
• W2897187561 hasConcept C2780580376 @default.
• W2897187561 hasConcept C2780873365 @default.
• W2897187561 hasConcept C2781413609 @default.
• W2897187561 hasConcept C2993143319 @default.
• W2897187561 hasConcept C71924100 @default.
• W2897187561 hasConcept C90924648 @default.
• W2897187561 hasConceptScore W2897187561C126322002 @default.
• W2897187561 hasConceptScore W2897187561C142462285 @default.
• W2897187561 hasConceptScore W2897187561C197934379 @default.
• W2897187561 hasConceptScore W2897187561C203014093 @default.
• W2897187561 hasConceptScore W2897187561C2522874641 @default.
• W2897187561 hasConceptScore W2897187561C2776408679 @default.
• W2897187561 hasConceptScore W2897187561C2776455275 @default.
• W2897187561 hasConceptScore W2897187561C2776461080 @default.
• W2897187561 hasConceptScore W2897187561C2776694085 @default.
• W2897187561 hasConceptScore W2897187561C2778375690 @default.
• W2897187561 hasConceptScore W2897187561C2778390639 @default.
• W2897187561 hasConceptScore W2897187561C2779298103 @default.
• W2897187561 hasConceptScore W2897187561C2780040827 @default.
• W2897187561 hasConceptScore W2897187561C2780580376 @default.
• W2897187561 hasConceptScore W2897187561C2780873365 @default.
• W2897187561 hasConceptScore W2897187561C2781413609 @default.
• W2897187561 hasConceptScore W2897187561C2993143319 @default.
• W2897187561 hasConceptScore W2897187561C71924100 @default.
• W2897187561 hasConceptScore W2897187561C90924648 @default.
• W2897187561 hasLocation W28971875611 @default.
• W2897187561 hasLocation W28971875612 @default.
• W2897187561 hasLocation W28971875613 @default.
• W2897187561 hasLocation W28971875614 @default.
• W2897187561 hasOpenAccess W2897187561 @default.
• W2897187561 hasPrimaryLocation W28971875611 @default.
• W2897187561 hasRelatedWork W1891692245 @default.
• W2897187561 hasRelatedWork W1965212035 @default.
• W2897187561 hasRelatedWork W1978099687 @default.
• W2897187561 hasRelatedWork W2035804055 @default.
• W2897187561 hasRelatedWork W2037648619 @default.
• W2897187561 hasRelatedWork W2075754452 @default.
• W2897187561 hasRelatedWork W2105947305 @default.
• W2897187561 hasRelatedWork W2310128032 @default.
• W2897187561 hasRelatedWork W2406874820 @default.
• W2897187561 hasRelatedWork W2581718718 @default.
• W2897187561 hasRelatedWork W2605798178 @default.
• W2897187561 hasRelatedWork W2606821326 @default.

• next