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- W2897208929 abstract "Magnesium is the fourth most abundant cation in the body. The adult human body contains a total of 1000 mmol of magnesium, of which 60% is in the bones and 20% in the skeletal muscles. Only 1% is extracellular and 39% is intracellular. Approximately 60% of serum magnesium is present as free magnesium ions, 30%–35% is protein-bound, and 5%–10% is complexed to bicarbonate, phosphate, and citrate. No single homeostatic control mechanism has been demonstrated for magnesium. The concentration of circulating magnesium is regulated by the intestinal tract, the kidney, and bone. These diuretics, usually referred to as potassium-sparing diuretics, are divided into two main classes: agents, whose action does not depend on the inhibition of aldosterone, and agents that are classical pharmacological competitive antagonists of aldosterone. Amiloride and triamterene are the main diuretics with action independent of the antagonism of aldosterone. The long-term effects of potassium-sparing diuretics on magnesium metabolism have not been extensively studied." @default.
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- W2897208929 date "1997-01-01" @default.
- W2897208929 modified "2023-09-27" @default.
- W2897208929 title "The Effects of Diuretics on Magnesium Metabolism" @default.
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- W2897208929 doi "https://doi.org/10.1016/b978-012635690-8/50037-2" @default.
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