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- W2897219461 abstract "Abstract Traumatic brain injury (TBI) is a global problem with a huge socioeconomic impact. Current understanding of the pathophysiology of TBI has led to a systematic approach towards management in the pre-hospital, operating theatre and critical care settings. Early management is directed towards protecting the brain from secondary injury. TBI is a spectrum of diseases, and rapid radiological identification of the underlying pathology is paramount to determine appropriate surgical intervention. Perioperative management frequently requires neurocritical care, with most modern centres using intracranial pressure and cerebral perfusion pressure targeted therapies. Decompressive craniectomy can be a useful mechanism to control medically refractory intracranial hypertension and reduce mortality; however, it also results in a spectrum of outcome categories and remains a controversial topic. Finally, there is emerging evidence that TBI is a chronic illness, with increased incidence of cognitive and behavioural deficits, neurodegenerative disease and an increased mortality that extends well beyond the initial TBI stage." @default.
- W2897219461 created "2018-10-26" @default.
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- W2897219461 date "2018-11-01" @default.
- W2897219461 modified "2023-10-16" @default.
- W2897219461 title "The management of traumatic brain injury" @default.
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- W2897219461 doi "https://doi.org/10.1016/j.mpsur.2018.09.007" @default.
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