FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897224234> ?p ?o ?g. }

• W2897224234 endingPage "493" @default.
• W2897224234 startingPage "483" @default.
• W2897224234 abstract "The glucocorticoid-induced leucine zipper (GILZ) mediates anti-inflammatory effects of glucocorticoids. Acute kidney injury (AKI) mobilizes immune/inflammatory mechanisms, causing tissue injury, but the impact of GILZ in AKI is not known. Neutrophils play context-specific proinflammatory [type 1 neutrophil (N1)] and anti-inflammatory [type 2 neutrophil (N2)] functional roles. Also, regulatory T lymphocytes (Tregs) and regulatory T-17 (Treg17) cells exert counterinflammatory effects, including the suppression of effector T lymphocytes [e.g., T-helper (Th) 17 cells]. Thus, utilizing cell preparations of mice kidneys subjected to AKI or sham operation, we determined the effects of GILZ on T cells and neutrophil subtypes in the context of its renoprotective effect; these studies used the transactivator of transcription (TAT)-GILZ or the TAT peptide. AKI increased N1 and Th-17 cells but reduced N2, Tregs, and Treg17 cells in association with increased interleukin (IL)-17⁺ but reduced IL-10⁺ cells accompanied with the disruption of mitochondrial membrane potential (<i>ψ</i>_m) and increased apoptosis/necrosis compared with sham kidneys. TAT-GILZ, compared with TAT, treatment reduced N1 and Th-17 cells but increased N2 and Tregs, without affecting Treg17 cells, in association with a reduction in IL-17⁺ cells but an increase in IL-10⁺ cells; TAT-GILZ caused less disruption of <i>ψ</i>_m and reduced cell death in AKI. Importantly, TAT-GILZ increased perfusion of the ischemic-reperfused kidney but reduced tissue edema compared with TAT. Utilizing splenic T cells and bone marrow–derived neutrophils, we further showed marked reduction in the proliferation of Th cells in response to TAT-GILZ compared with response to TAT. Collectively, the results indicate that GILZ exerts renoprotection accompanied by the upregulation of the regulatory/suppressive arm of immunity in AKI, likely via regulating cross talk between T cells and neutrophils." @default.
• W2897224234 created "2018-10-26" @default.
• W2897224234 creator A5011681716 @default.
• W2897224234 creator A5029547477 @default.
• W2897224234 creator A5037472655 @default.
• W2897224234 creator A5040903128 @default.
• W2897224234 creator A5049190064 @default.
• W2897224234 creator A5062387136 @default.
• W2897224234 creator A5073526459 @default.
• W2897224234 creator A5077751341 @default.
• W2897224234 creator A5085341589 @default.
• W2897224234 date "2018-10-09" @default.
• W2897224234 modified "2023-09-23" @default.
• W2897224234 title "Glucocorticoid-Induced Leucine Zipper Promotes Neutrophil and T-Cell Polarization with Protective Effects in Acute Kidney Injury" @default.
• W2897224234 cites W1771162562 @default.
• W2897224234 cites W1833987578 @default.
• W2897224234 cites W1932918058 @default.
• W2897224234 cites W1949260419 @default.
• W2897224234 cites W1964536962 @default.
• W2897224234 cites W1985099579 @default.
• W2897224234 cites W1986240011 @default.
• W2897224234 cites W1994320316 @default.
• W2897224234 cites W1996568534 @default.
• W2897224234 cites W2007767660 @default.
• W2897224234 cites W2008487520 @default.
• W2897224234 cites W2010449491 @default.
• W2897224234 cites W2021502452 @default.
• W2897224234 cites W2028628211 @default.
• W2897224234 cites W2029640857 @default.
• W2897224234 cites W2032449668 @default.
• W2897224234 cites W2034036532 @default.
• W2897224234 cites W2035170959 @default.
• W2897224234 cites W2047124888 @default.
• W2897224234 cites W2049934590 @default.
• W2897224234 cites W2055876243 @default.
• W2897224234 cites W2063861465 @default.
• W2897224234 cites W2067181732 @default.
• W2897224234 cites W2068382121 @default.
• W2897224234 cites W2070822717 @default.
• W2897224234 cites W2078813176 @default.
• W2897224234 cites W2092134437 @default.
• W2897224234 cites W2092698158 @default.
• W2897224234 cites W2099540110 @default.
• W2897224234 cites W2105305350 @default.
• W2897224234 cites W2105905036 @default.
• W2897224234 cites W2112687470 @default.
• W2897224234 cites W2135613694 @default.
• W2897224234 cites W2145761681 @default.
• W2897224234 cites W2147207093 @default.
• W2897224234 cites W2148622539 @default.
• W2897224234 cites W2148971650 @default.
• W2897224234 cites W2149190057 @default.
• W2897224234 cites W2150692938 @default.
• W2897224234 cites W2212574367 @default.
• W2897224234 cites W2220775330 @default.
• W2897224234 cites W2233632661 @default.
• W2897224234 cites W2286929259 @default.
• W2897224234 cites W23360501 @default.
• W2897224234 cites W2430394288 @default.
• W2897224234 cites W2470268848 @default.
• W2897224234 cites W2512431105 @default.
• W2897224234 cites W2520712804 @default.
• W2897224234 cites W2550076413 @default.
• W2897224234 cites W2604622155 @default.
• W2897224234 cites W2606100543 @default.
• W2897224234 cites W2613076035 @default.
• W2897224234 cites W2738111264 @default.
• W2897224234 cites W2743014511 @default.
• W2897224234 cites W2743806965 @default.
• W2897224234 cites W2805839476 @default.
• W2897224234 cites W2808620289 @default.
• W2897224234 cites W4238252095 @default.
• W2897224234 cites W4249286796 @default.
• W2897224234 cites W632080592 @default.
• W2897224234 cites W2013693982 @default.
• W2897224234 doi "https://doi.org/10.1124/jpet.118.251371" @default.
• W2897224234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30301736" @default.
• W2897224234 hasPublicationYear "2018" @default.
• W2897224234 type Work @default.
• W2897224234 sameAs 2897224234 @default.
• W2897224234 citedByCount "20" @default.
• W2897224234 countsByYear W28972242342019 @default.
• W2897224234 countsByYear W28972242342020 @default.
• W2897224234 countsByYear W28972242342021 @default.
• W2897224234 countsByYear W28972242342022 @default.
• W2897224234 countsByYear W28972242342023 @default.
• W2897224234 crossrefType "journal-article" @default.
• W2897224234 hasAuthorship W2897224234A5011681716 @default.
• W2897224234 hasAuthorship W2897224234A5029547477 @default.
• W2897224234 hasAuthorship W2897224234A5037472655 @default.
• W2897224234 hasAuthorship W2897224234A5040903128 @default.
• W2897224234 hasAuthorship W2897224234A5049190064 @default.
• W2897224234 hasAuthorship W2897224234A5062387136 @default.
• W2897224234 hasAuthorship W2897224234A5073526459 @default.
• W2897224234 hasAuthorship W2897224234A5077751341 @default.
• W2897224234 hasAuthorship W2897224234A5085341589 @default.
• W2897224234 hasBestOaLocation W28972242341 @default.
• W2897224234 hasConcept C104317684 @default.

• next