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- W2897230620 abstract "Patients with malignant tumor treated with immunotherapy have received significant clinical benefits over the years. Immune checkpoint blocking agents, such as anti-cytotoxic T-lymphocyte-associated protein-4 (anti-CTLA-4) and anti-programmed cell death protein-1 (anti-PD-1) monoclonal antibodies, have produced impressive clinical results in different types of cancer. T-cell immunoglobulin and mucin domain-3 (TIM-3), another immune checkpoint, could inhibit cancer immunity. Recent studies have highlighted that TIM-3 has an important role to play in T-cell exhaustion and correlates with the outcome of anti-PD-1 therapy. Targeting TIM-3 might be a promising approach for cancer immunotherapy. Here, we review the role of TIM-3 in cancer and clinical trials with TIM-3 inhibitors." @default.
- W2897230620 created "2018-10-26" @default.
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- W2897230620 date "2018-10-01" @default.
- W2897230620 modified "2023-10-11" @default.
- W2897230620 title "TIM-3, a promising target for cancer immunotherapy" @default.
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- W2897230620 doi "https://doi.org/10.2147/ott.s170385" @default.
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