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- W2897250290 abstract "Dyes which photosensitize membranes may be clinically useful for photodynamic treatment (PDT) of herpes simplex virus (HSV) infections. It is unknown whether inactivation of HSV can be accomplished by damaging its membrane envelope without also affecting its genetic material. Thus, selection of optimal PDT conditions should include choosing a dye which minimizes viral mutagenesis. We compared the mutagenesis caused by PDT employing each of three membrane-sensitizing dyes of potential use in cancer photochemotherapy (Photofrin II, polyhematoporphyrin esters, zinc phthalocyanine tetrasulfonates) or a DNA photosensitizing dye (proflavine sulfate) with the mutagenesis caused by exposure of HSV to ultraviolet radiation (UV). The procedure consisted of incubating HSV with micromolar concentrations of the dye and irradiating the samples with broadband radiation (Daylight fluorescent lamps). In parallel with determination of HSV survival, progeny of the surviving virus were grown for determination of mutagenesis. The progeny virus were harvested and assayed to determine the frequency of mutation to iododeoxycytidine (ICrd) resistance. Mutation frequencies were determined for progeny from the 1-6% survival level. For PDT with membrane-sensitizing dyes, only zinc phthalocyanine increased the mutation frequency over the untreated control. This increase was less than 2-fold. Proflavine increased the mutation frequency 2-3 fold. UV produced an approximately 20-fold increase. Therefore, all four dyes were much less mutagenic than UV, and the membrane-sensitizing dyes were less mutagenic than the DNA-sensitizing proflavine.Dyes which photosensitize membranes may be clinically useful for photodynamic treatment (PDT) of herpes simplex virus (HSV) infections. It is unknown whether inactivation of HSV can be accomplished by damaging its membrane envelope without also affecting its genetic material. Thus, selection of optimal PDT conditions should include choosing a dye which minimizes viral mutagenesis. We compared the mutagenesis caused by PDT employing each of three membrane-sensitizing dyes of potential use in cancer photochemotherapy (Photofrin II, polyhematoporphyrin esters, zinc phthalocyanine tetrasulfonates) or a DNA photosensitizing dye (proflavine sulfate) with the mutagenesis caused by exposure of HSV to ultraviolet radiation (UV). The procedure consisted of incubating HSV with micromolar concentrations of the dye and irradiating the samples with broadband radiation (Daylight fluorescent lamps). In parallel with determination of HSV survival, progeny of the surviving virus were grown for determination of mutagenesis...." @default.
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- W2897250290 date "1988-01-01" @default.
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- W2897250290 title "Mutagenesis of herpesvirus by different photodynamic treatments" @default.
- W2897250290 doi "https://doi.org/10.2351/1.5057964" @default.
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