FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897250799> ?p ?o ?g. }

• W2897250799 endingPage "1697" @default.
• W2897250799 startingPage "1689" @default.
• W2897250799 abstract "Purpose. Clostridium difficile is an anaerobic spore-forming bacterial pathogen that causes a spectrum of illness severity ranging from mild diarrhoea to severe life-threatening pseudomembranous colitis. C. difficile infection (CDI) is antibiotic-associated and primarily mediated by two exotoxins, Toxins A and B. We and others have shown that some antibiotics stimulate Toxin A and B production by C. difficile in a strain-specific manner. Still, the effects of newer anti-C. difficile antibiotics on this process and spore formation remain to be investigated. Methodology. Surotomycin (formally CB-183,315) is a novel, minimally absorbed, narrow-spectrum antibiotic. We determined the effects of surotomycin on C. difficile growth, toxin production and sporulation in historical and BI/NAP1/027 epidemic strains of C. difficile. Results/Key findings. While antibiotic free controls showed toxin production during the stationary phase growth, all strains exposed to sub-inhibitory concentrations of surotomycin and vancomycin demonstrated increased TcdA and TcdB production during early (log phase) growth by all strains. However, this effect was not observed at 24 or 48 h post-treatment by any of the C. difficile strains exposed to either antibiotic. Additionally, all doses of surotomycin and vancomycin suppressed spore formation in all tested strains. Conclusion. In summary, these findings demonstrate that surotomycin and vancomycin have similar effects on exotoxin production and sporulation by C. difficile in vitro. Furthermore, since spores contribute to recurrent infection, the ability of surotomycin to suppress spore formation may explain its ability to disrupt the reinfection cycle in the clinical setting." @default.
• W2897250799 created "2018-10-26" @default.
• W2897250799 creator A5062031102 @default.
• W2897250799 creator A5062594893 @default.
• W2897250799 creator A5062657135 @default.
• W2897250799 creator A5068572980 @default.
• W2897250799 creator A5081263864 @default.
• W2897250799 date "2018-12-01" @default.
• W2897250799 modified "2023-09-26" @default.
• W2897250799 title "Sub-lethal doses of surotomycin and vancomycin have similar effects on Clostridium difficile virulence factor production in vitro" @default.
• W2897250799 cites W1577885969 @default.
• W2897250799 cites W1963553950 @default.
• W2897250799 cites W1973425330 @default.
• W2897250799 cites W1976915127 @default.
• W2897250799 cites W1992379400 @default.
• W2897250799 cites W1995242310 @default.
• W2897250799 cites W1998680029 @default.
• W2897250799 cites W2056233231 @default.
• W2897250799 cites W2084193745 @default.
• W2897250799 cites W2092120669 @default.
• W2897250799 cites W2096350108 @default.
• W2897250799 cites W2097707684 @default.
• W2897250799 cites W2113335688 @default.
• W2897250799 cites W2113556993 @default.
• W2897250799 cites W2117034033 @default.
• W2897250799 cites W2139039522 @default.
• W2897250799 cites W2141951202 @default.
• W2897250799 cites W2148529820 @default.
• W2897250799 cites W2154900496 @default.
• W2897250799 cites W2166602148 @default.
• W2897250799 cites W2202785594 @default.
• W2897250799 cites W2323361437 @default.
• W2897250799 cites W2501981640 @default.
• W2897250799 cites W2588484778 @default.
• W2897250799 cites W2752378836 @default.
• W2897250799 cites W2791326569 @default.
• W2897250799 cites W4246859168 @default.
• W2897250799 cites W4251404301 @default.
• W2897250799 doi "https://doi.org/10.1099/jmm.0.000852" @default.
• W2897250799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6557148" @default.
• W2897250799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30307842" @default.
• W2897250799 hasPublicationYear "2018" @default.
• W2897250799 type Work @default.
• W2897250799 sameAs 2897250799 @default.
• W2897250799 citedByCount "1" @default.
• W2897250799 countsByYear W28972507992022 @default.
• W2897250799 crossrefType "journal-article" @default.
• W2897250799 hasAuthorship W2897250799A5062031102 @default.
• W2897250799 hasAuthorship W2897250799A5062594893 @default.
• W2897250799 hasAuthorship W2897250799A5062657135 @default.
• W2897250799 hasAuthorship W2897250799A5068572980 @default.
• W2897250799 hasAuthorship W2897250799A5081263864 @default.
• W2897250799 hasBestOaLocation W28972507991 @default.
• W2897250799 hasConcept C104317684 @default.
• W2897250799 hasConcept C174618031 @default.
• W2897250799 hasConcept C2776460866 @default.
• W2897250799 hasConcept C2777367657 @default.
• W2897250799 hasConcept C2778723905 @default.
• W2897250799 hasConcept C2778980435 @default.
• W2897250799 hasConcept C2779489039 @default.
• W2897250799 hasConcept C2781092032 @default.
• W2897250799 hasConcept C2991793726 @default.
• W2897250799 hasConcept C2994496256 @default.
• W2897250799 hasConcept C501593827 @default.
• W2897250799 hasConcept C523546767 @default.
• W2897250799 hasConcept C54355233 @default.
• W2897250799 hasConcept C55493867 @default.
• W2897250799 hasConcept C60987743 @default.
• W2897250799 hasConcept C86803240 @default.
• W2897250799 hasConcept C89423630 @default.
• W2897250799 hasConcept C97505648 @default.
• W2897250799 hasConceptScore W2897250799C104317684 @default.
• W2897250799 hasConceptScore W2897250799C174618031 @default.
• W2897250799 hasConceptScore W2897250799C2776460866 @default.
• W2897250799 hasConceptScore W2897250799C2777367657 @default.
• W2897250799 hasConceptScore W2897250799C2778723905 @default.
• W2897250799 hasConceptScore W2897250799C2778980435 @default.
• W2897250799 hasConceptScore W2897250799C2779489039 @default.
• W2897250799 hasConceptScore W2897250799C2781092032 @default.
• W2897250799 hasConceptScore W2897250799C2991793726 @default.
• W2897250799 hasConceptScore W2897250799C2994496256 @default.
• W2897250799 hasConceptScore W2897250799C501593827 @default.
• W2897250799 hasConceptScore W2897250799C523546767 @default.
• W2897250799 hasConceptScore W2897250799C54355233 @default.
• W2897250799 hasConceptScore W2897250799C55493867 @default.
• W2897250799 hasConceptScore W2897250799C60987743 @default.
• W2897250799 hasConceptScore W2897250799C86803240 @default.
• W2897250799 hasConceptScore W2897250799C89423630 @default.
• W2897250799 hasConceptScore W2897250799C97505648 @default.
• W2897250799 hasIssue "12" @default.
• W2897250799 hasLocation W28972507991 @default.
• W2897250799 hasLocation W28972507992 @default.
• W2897250799 hasLocation W28972507993 @default.
• W2897250799 hasLocation W28972507994 @default.
• W2897250799 hasOpenAccess W2897250799 @default.
• W2897250799 hasPrimaryLocation W28972507991 @default.
• W2897250799 hasRelatedWork W1980697150 @default.
• W2897250799 hasRelatedWork W2025024815 @default.

• next