FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897254858> ?p ?o ?g. }

• W2897254858 abstract "The brain perivascular space is a route of fluid flow serving to maintain brain homeostasis[1, 2]. Recent studies have shown clearance of interstitial wastes including Aβ by way of the perivascular compartment[2]. Pathological enlargement of perivascular spaces (ePVS) recently has been considered in the context of Alzheimer's[3, 4] and amyloid pathologies[5, 6]. Using novel automated methods for automatically segmenting ePVS in MRI, we evaluated regional ePVS characteristics and amyloid burden in subjects from the ADNI repository. T1 images from 96 ADNI datasets (Table 1) were used to segment white matter (WM) and gray matter compartments (Freesurfer). A modified automated method was applied to segment ePVS based on voxel intensity (AFNI) and per ePVS morphological characteristics (MATLAB)[7]. Deep WM voxels were parcellated by the relative frequency of lobar membership in surrounding juxtacortical WM (FreeSurfer). A k-nearest neighbor algorithm was applied to measure the distance between the ePVS and the cortical ribbon (MATLAB). Clinical, demographic, CSF amyloid, and binary Florbetapir positivity[8] were obtained from the ADNI repository. See Table for summary participant characteristics including ePVS morphology. Frontal and parietal lobes contained the largest normalized count and volume of ePVS compared to occipital and temporal lobes (t(95)=12.5 and 13.6, respectively, p<.0001), although larger (volume, width, length) ePVS localized to occipital and parietal lobes (Figure 2). Age was positively associated with ePVS volume and count (R= 0.34, p <0.001). In amyloid positive participants, high CSF Aβ was associated with low ePVS burden in occipital and parietal regions (p<0.01, p<0.05, respectively, Figure 3) . Per ePVS characteristics by lobe (top row) and whole brain (bottom row). Whole brain per-unit-tissue-volume ePVS counts and volumes by lobe (left) and a probability map overlaid on a standard brain (right). Relationship between lobar ePVS burden and CSF Aβ among Amyloid PET positive (blue dots) and negative (black dots) subjects. Among amyloid positive subjects, there was a significant relationship between high CSF Aβ and low ePVS burden in the parietal and occipital lobe, specifically. This report is the first to characterize regional and morphological ePVS in the ADNI datasets and the first to identify regional ePVS with respect to amyloid burden. While frontal and parietal regions had the highest ePVS per unit tissue volume, findings of highest cluster-wise volume in the occipital lobe, in tandem with observations that this region was particularly sensitive to the relationship between amyloid and ePVS, suggest differential draining/clearance characteristics by region. Further analysis of regional amyloid deposition in relation to these findings could provide important insight into the role of ePVS in amyloid clearance and AD risk." @default.
• W2897254858 created "2018-10-26" @default.
• W2897254858 creator A5034270911 @default.
• W2897254858 creator A5039876398 @default.
• W2897254858 creator A5051808588 @default.
• W2897254858 creator A5087173048 @default.
• W2897254858 date "2018-07-01" @default.
• W2897254858 modified "2023-10-16" @default.
• W2897254858 title "P2‐425: REGIONAL AND MORPHOLOGICAL CHARACTERISTICS OF ENLARGED PERIVASCULAR SPACES IN RELATIONSHIP TO AMYLOID PET AND CSF Aβ IN ADNI DATASETS" @default.
• W2897254858 doi "https://doi.org/10.1016/j.jalz.2018.06.1117" @default.
• W2897254858 hasPublicationYear "2018" @default.
• W2897254858 type Work @default.
• W2897254858 sameAs 2897254858 @default.
• W2897254858 citedByCount "0" @default.
• W2897254858 crossrefType "journal-article" @default.
• W2897254858 hasAuthorship W2897254858A5034270911 @default.
• W2897254858 hasAuthorship W2897254858A5039876398 @default.
• W2897254858 hasAuthorship W2897254858A5051808588 @default.
• W2897254858 hasAuthorship W2897254858A5087173048 @default.
• W2897254858 hasConcept C105702510 @default.
• W2897254858 hasConcept C126838900 @default.
• W2897254858 hasConcept C142724271 @default.
• W2897254858 hasConcept C143409427 @default.
• W2897254858 hasConcept C15744967 @default.
• W2897254858 hasConcept C169760540 @default.
• W2897254858 hasConcept C185592680 @default.
• W2897254858 hasConcept C2777633098 @default.
• W2897254858 hasConcept C2777799939 @default.
• W2897254858 hasConcept C2781192897 @default.
• W2897254858 hasConcept C2989005 @default.
• W2897254858 hasConcept C54170458 @default.
• W2897254858 hasConcept C58693492 @default.
• W2897254858 hasConcept C71924100 @default.
• W2897254858 hasConcept C82233179 @default.
• W2897254858 hasConceptScore W2897254858C105702510 @default.
• W2897254858 hasConceptScore W2897254858C126838900 @default.
• W2897254858 hasConceptScore W2897254858C142724271 @default.
• W2897254858 hasConceptScore W2897254858C143409427 @default.
• W2897254858 hasConceptScore W2897254858C15744967 @default.
• W2897254858 hasConceptScore W2897254858C169760540 @default.
• W2897254858 hasConceptScore W2897254858C185592680 @default.
• W2897254858 hasConceptScore W2897254858C2777633098 @default.
• W2897254858 hasConceptScore W2897254858C2777799939 @default.
• W2897254858 hasConceptScore W2897254858C2781192897 @default.
• W2897254858 hasConceptScore W2897254858C2989005 @default.
• W2897254858 hasConceptScore W2897254858C54170458 @default.
• W2897254858 hasConceptScore W2897254858C58693492 @default.
• W2897254858 hasConceptScore W2897254858C71924100 @default.
• W2897254858 hasConceptScore W2897254858C82233179 @default.
• W2897254858 hasIssue "7S_Part_16" @default.
• W2897254858 hasLocation W28972548581 @default.
• W2897254858 hasOpenAccess W2897254858 @default.
• W2897254858 hasPrimaryLocation W28972548581 @default.
• W2897254858 hasRelatedWork W1492188803 @default.
• W2897254858 hasRelatedWork W2020782566 @default.
• W2897254858 hasRelatedWork W2065524737 @default.
• W2897254858 hasRelatedWork W2076180413 @default.
• W2897254858 hasRelatedWork W2109315697 @default.
• W2897254858 hasRelatedWork W2109814290 @default.
• W2897254858 hasRelatedWork W2166305102 @default.
• W2897254858 hasRelatedWork W2406698057 @default.
• W2897254858 hasRelatedWork W2771176174 @default.
• W2897254858 hasRelatedWork W3030874049 @default.
• W2897254858 hasVolume "14" @default.
• W2897254858 isParatext "false" @default.
• W2897254858 isRetracted "false" @default.
• W2897254858 magId "2897254858" @default.
• W2897254858 workType "article" @default.