Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897281558> ?p ?o ?g. }
- W2897281558 endingPage "2574" @default.
- W2897281558 startingPage "2563" @default.
- W2897281558 abstract "Abstract Microglial activation, increased proinflammatory cytokine production, and a reduction in synaptic density are key pathological features associated with HIV‐associated neurocognitive disorders (HAND). Even with combination antiretroviral therapy (cART), more than 50% of HIV‐positive individuals experience some type of cognitive impairment. Although viral replication is inhibited by cART, HIV proteins such as Tat are still produced within the nervous system that are neurotoxic, involved in synapse elimination, and provoke enduring neuroinflammation. As complement deposition on synapses followed by microglial engulfment has been shown during normal development and disease to be a mechanism for pruning synapses, we have tested whether complement is required for the loss of synapses that occurs after a cortical Tat injection mouse model of HAND. In Tat‐injected animals evaluated 7 or 28 days after injection, levels of early complement pathway components, C1q and C3, are significantly elevated and associated with microgliosis and a loss of synapses. However, C1qa knockout mice have the same level of Tat‐induced synapse loss as wild‐type (WT) mice, showing that the C1q‐initiated classical complement cascade is not driving synapse removal during HIV1 Tat‐induced neuroinflammation." @default.
- W2897281558 created "2018-10-26" @default.
- W2897281558 creator A5012563424 @default.
- W2897281558 creator A5031088799 @default.
- W2897281558 creator A5031413583 @default.
- W2897281558 creator A5033967453 @default.
- W2897281558 creator A5060145237 @default.
- W2897281558 creator A5071361515 @default.
- W2897281558 creator A5076109995 @default.
- W2897281558 creator A5090371250 @default.
- W2897281558 date "2018-10-16" @default.
- W2897281558 modified "2023-10-14" @default.
- W2897281558 title "HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q" @default.
- W2897281558 cites W1456373634 @default.
- W2897281558 cites W1629767297 @default.
- W2897281558 cites W1972734935 @default.
- W2897281558 cites W1979476762 @default.
- W2897281558 cites W1984619011 @default.
- W2897281558 cites W1988487618 @default.
- W2897281558 cites W1989354537 @default.
- W2897281558 cites W1996476108 @default.
- W2897281558 cites W1999419270 @default.
- W2897281558 cites W1999613356 @default.
- W2897281558 cites W2009905886 @default.
- W2897281558 cites W2015684766 @default.
- W2897281558 cites W2016912126 @default.
- W2897281558 cites W2021061796 @default.
- W2897281558 cites W2023813976 @default.
- W2897281558 cites W2026397702 @default.
- W2897281558 cites W2026823968 @default.
- W2897281558 cites W2028685883 @default.
- W2897281558 cites W2028723159 @default.
- W2897281558 cites W2029906813 @default.
- W2897281558 cites W2032870346 @default.
- W2897281558 cites W2032940358 @default.
- W2897281558 cites W2033102468 @default.
- W2897281558 cites W2033617297 @default.
- W2897281558 cites W2044455774 @default.
- W2897281558 cites W2044495960 @default.
- W2897281558 cites W2048057207 @default.
- W2897281558 cites W2052543965 @default.
- W2897281558 cites W2066331806 @default.
- W2897281558 cites W2066790775 @default.
- W2897281558 cites W2067217824 @default.
- W2897281558 cites W2071619398 @default.
- W2897281558 cites W2096327192 @default.
- W2897281558 cites W2102273738 @default.
- W2897281558 cites W2107673722 @default.
- W2897281558 cites W2116505573 @default.
- W2897281558 cites W2124777889 @default.
- W2897281558 cites W2138284015 @default.
- W2897281558 cites W2223528584 @default.
- W2897281558 cites W2233550869 @default.
- W2897281558 cites W2255138985 @default.
- W2897281558 cites W2314634699 @default.
- W2897281558 cites W2341088037 @default.
- W2897281558 cites W2351778937 @default.
- W2897281558 cites W2408820813 @default.
- W2897281558 cites W2465063465 @default.
- W2897281558 cites W2471701648 @default.
- W2897281558 cites W2533123805 @default.
- W2897281558 cites W2559384874 @default.
- W2897281558 cites W2571191660 @default.
- W2897281558 cites W2582048941 @default.
- W2897281558 cites W2594556782 @default.
- W2897281558 cites W2611499966 @default.
- W2897281558 cites W2622909676 @default.
- W2897281558 cites W2734679532 @default.
- W2897281558 cites W2744214718 @default.
- W2897281558 cites W2753366322 @default.
- W2897281558 cites W2765508996 @default.
- W2897281558 cites W2769486295 @default.
- W2897281558 cites W2811414271 @default.
- W2897281558 doi "https://doi.org/10.1002/glia.23511" @default.
- W2897281558 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309507" @default.
- W2897281558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30325063" @default.
- W2897281558 hasPublicationYear "2018" @default.
- W2897281558 type Work @default.
- W2897281558 sameAs 2897281558 @default.
- W2897281558 citedByCount "13" @default.
- W2897281558 countsByYear W28972815582019 @default.
- W2897281558 countsByYear W28972815582020 @default.
- W2897281558 countsByYear W28972815582021 @default.
- W2897281558 countsByYear W28972815582022 @default.
- W2897281558 countsByYear W28972815582023 @default.
- W2897281558 crossrefType "journal-article" @default.
- W2897281558 hasAuthorship W2897281558A5012563424 @default.
- W2897281558 hasAuthorship W2897281558A5031088799 @default.
- W2897281558 hasAuthorship W2897281558A5031413583 @default.
- W2897281558 hasAuthorship W2897281558A5033967453 @default.
- W2897281558 hasAuthorship W2897281558A5060145237 @default.
- W2897281558 hasAuthorship W2897281558A5071361515 @default.
- W2897281558 hasAuthorship W2897281558A5076109995 @default.
- W2897281558 hasAuthorship W2897281558A5090371250 @default.
- W2897281558 hasBestOaLocation W28972815582 @default.
- W2897281558 hasConcept C111684460 @default.
- W2897281558 hasConcept C127445978 @default.
- W2897281558 hasConcept C164027704 @default.