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• W2897300390 abstract "Glia constitute roughly half of the cells of the central nervous system (CNS) but were long-considered to be static bystanders to its formation and function. Here we provide an overview of how the diverse and dynamic functions of glial cells orchestrate essentially all aspects of nervous system formation and function. Radial glia, astrocytes, oligodendrocyte progenitor cells, oligodendrocytes, and microglia each influence nervous system development, from neuronal birth, migration, axon specification, and growth through circuit assembly and synaptogenesis. As neural circuits mature, distinct glia fulfill key roles in synaptic communication, plasticity, homeostasis, and network-level activity through dynamic monitoring and alteration of CNS structure and function. Continued elucidation of glial cell biology, and the dynamic interactions of neurons and glia, will enrich our understanding of nervous system formation, health, and function." @default.
• W2897300390 created "2018-10-26" @default.
• W2897300390 creator A5036232769 @default.
• W2897300390 creator A5081113617 @default.
• W2897300390 date "2018-10-12" @default.
• W2897300390 modified "2023-10-11" @default.
• W2897300390 title "Glia as architects of central nervous system formation and function" @default.
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• W2897300390 doi "https://doi.org/10.1126/science.aat0473" @default.
• W2897300390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6292669" @default.
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• W2897300390 hasPublicationYear "2018" @default.
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