Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897300821> ?p ?o ?g. }
- W2897300821 endingPage "748.e4" @default.
- W2897300821 startingPage "737" @default.
- W2897300821 abstract "Despite advances made in understanding the effects of promoter structure on transcriptional activity, limited knowledge exists regarding the role played by chromatin architecture in transcription. Previous work hypothesized that transcription from the bidirectional GAL1/GAL10 promoter is controlled through looping of its UAS region around a nonstandard nucleosome. Here, by editing the GAL1/GAL10 promoter at high resolution, we provide insights into bidirectional expression control. We demonstrate that the first and fourth Gal4 binding sites within the UAS do not functionally contribute to promoter activation. Instead, these sites, along with nearby regulatory regions, contribute to the directional regulation of gene expression. Furthermore, Gal4 binding to the third binding site is critical for gene expression, while binding to the other three sites is not sufficient for transcriptional activation. Because the GAL1/GAL10 UAS can activate gene expression in many eukaryotes, the regulatory mechanism presented is expected to operate broadly across the eukaryotic clade." @default.
- W2897300821 created "2018-10-26" @default.
- W2897300821 creator A5003715208 @default.
- W2897300821 creator A5008310387 @default.
- W2897300821 creator A5032896185 @default.
- W2897300821 creator A5065066488 @default.
- W2897300821 date "2018-10-01" @default.
- W2897300821 modified "2023-09-26" @default.
- W2897300821 title "Insights into Bidirectional Gene Expression Control Using the Canonical GAL1/GAL10 Promoter" @default.
- W2897300821 cites W1611419455 @default.
- W2897300821 cites W1805506162 @default.
- W2897300821 cites W1855382658 @default.
- W2897300821 cites W187623135 @default.
- W2897300821 cites W1986723677 @default.
- W2897300821 cites W1987900665 @default.
- W2897300821 cites W1994032485 @default.
- W2897300821 cites W1996234405 @default.
- W2897300821 cites W2048880554 @default.
- W2897300821 cites W2054624670 @default.
- W2897300821 cites W2057968948 @default.
- W2897300821 cites W2058638956 @default.
- W2897300821 cites W2090732700 @default.
- W2897300821 cites W2094075502 @default.
- W2897300821 cites W2095771622 @default.
- W2897300821 cites W2105522597 @default.
- W2897300821 cites W2115420193 @default.
- W2897300821 cites W2119714784 @default.
- W2897300821 cites W2122576785 @default.
- W2897300821 cites W2125235548 @default.
- W2897300821 cites W2167389868 @default.
- W2897300821 cites W2169142563 @default.
- W2897300821 cites W2528055985 @default.
- W2897300821 cites W2569598062 @default.
- W2897300821 cites W2742189960 @default.
- W2897300821 cites W2756220382 @default.
- W2897300821 cites W2806459091 @default.
- W2897300821 cites W4238133297 @default.
- W2897300821 cites W4239406033 @default.
- W2897300821 doi "https://doi.org/10.1016/j.celrep.2018.09.050" @default.
- W2897300821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6263159" @default.
- W2897300821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30332652" @default.
- W2897300821 hasPublicationYear "2018" @default.
- W2897300821 type Work @default.
- W2897300821 sameAs 2897300821 @default.
- W2897300821 citedByCount "16" @default.
- W2897300821 countsByYear W28973008212019 @default.
- W2897300821 countsByYear W28973008212020 @default.
- W2897300821 countsByYear W28973008212021 @default.
- W2897300821 countsByYear W28973008212022 @default.
- W2897300821 countsByYear W28973008212023 @default.
- W2897300821 crossrefType "journal-article" @default.
- W2897300821 hasAuthorship W2897300821A5003715208 @default.
- W2897300821 hasAuthorship W2897300821A5008310387 @default.
- W2897300821 hasAuthorship W2897300821A5032896185 @default.
- W2897300821 hasAuthorship W2897300821A5065066488 @default.
- W2897300821 hasBestOaLocation W28973008211 @default.
- W2897300821 hasConcept C101762097 @default.
- W2897300821 hasConcept C104317684 @default.
- W2897300821 hasConcept C138885662 @default.
- W2897300821 hasConcept C150194340 @default.
- W2897300821 hasConcept C165864922 @default.
- W2897300821 hasConcept C179926584 @default.
- W2897300821 hasConcept C41895202 @default.
- W2897300821 hasConcept C54355233 @default.
- W2897300821 hasConcept C70721500 @default.
- W2897300821 hasConcept C83640560 @default.
- W2897300821 hasConcept C86339819 @default.
- W2897300821 hasConcept C86803240 @default.
- W2897300821 hasConcept C95444343 @default.
- W2897300821 hasConceptScore W2897300821C101762097 @default.
- W2897300821 hasConceptScore W2897300821C104317684 @default.
- W2897300821 hasConceptScore W2897300821C138885662 @default.
- W2897300821 hasConceptScore W2897300821C150194340 @default.
- W2897300821 hasConceptScore W2897300821C165864922 @default.
- W2897300821 hasConceptScore W2897300821C179926584 @default.
- W2897300821 hasConceptScore W2897300821C41895202 @default.
- W2897300821 hasConceptScore W2897300821C54355233 @default.
- W2897300821 hasConceptScore W2897300821C70721500 @default.
- W2897300821 hasConceptScore W2897300821C83640560 @default.
- W2897300821 hasConceptScore W2897300821C86339819 @default.
- W2897300821 hasConceptScore W2897300821C86803240 @default.
- W2897300821 hasConceptScore W2897300821C95444343 @default.
- W2897300821 hasFunder F4320332161 @default.
- W2897300821 hasIssue "3" @default.
- W2897300821 hasLocation W28973008211 @default.
- W2897300821 hasLocation W28973008212 @default.
- W2897300821 hasLocation W28973008213 @default.
- W2897300821 hasLocation W28973008214 @default.
- W2897300821 hasLocation W28973008215 @default.
- W2897300821 hasOpenAccess W2897300821 @default.
- W2897300821 hasPrimaryLocation W28973008211 @default.
- W2897300821 hasRelatedWork W1818003313 @default.
- W2897300821 hasRelatedWork W2009966535 @default.
- W2897300821 hasRelatedWork W2012391942 @default.
- W2897300821 hasRelatedWork W2111182449 @default.
- W2897300821 hasRelatedWork W2121924440 @default.
- W2897300821 hasRelatedWork W2172226517 @default.
- W2897300821 hasRelatedWork W2549332635 @default.