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- W2897310500 endingPage "e12963" @default.
- W2897310500 startingPage "e12963" @default.
- W2897310500 abstract "Candida albicans is an opportunistic fungal pathogen that colonises the skin as well as genital and intestinal mucosa of most healthy individuals. The ability of C. albicans to switch between different morphological states, for example, from an ellipsoid yeast form to a highly polarised, hyphal form, contributes to its success as a pathogen. In highly polarised tip-growing cells such as neurons, pollen tubes, and filamentous fungi, delivery of membrane and cargo to the filament apex is achieved by long-range delivery of secretory vesicles tethered to motors moving along cytoskeletal cables that extend towards the growing tip. To investigate whether such a mechanism is also critical for C. albicans filamentous growth, we studied the dynamics and organisation of the C. albicans secretory pathway using live cell imaging and three-dimensional electron microscopy. We demonstrate that the secretory pathway is organised in distinct domains, including endoplasmic reticulum membrane sheets that extend along the length of the hyphal filament, a sub-apical zone exhibiting distinct membrane structures and dynamics and a Spitzenkörper comprised of uniformly sized secretory vesicles. Our results indicate that the organisation of the secretory pathway in C. albicans likely facilitates short-range on-site secretory vesicle delivery, in contrast to filamentous fungi and many highly polarised cells." @default.
- W2897310500 created "2018-10-26" @default.
- W2897310500 creator A5022712252 @default.
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- W2897310500 date "2018-11-08" @default.
- W2897310500 modified "2023-10-17" @default.
- W2897310500 title "On‐site secretory vesicle delivery drives filamentous growth in the fungal pathogen<scp><i>Candida albicans</i></scp>" @default.
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- W2897310500 doi "https://doi.org/10.1111/cmi.12963" @default.
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- W2897310500 hasPublicationYear "2018" @default.
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