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- W2897312639 abstract "Background: PPAR-γ and PRDM16 proteins have key role in the metabolism of adipose tissue andthe conversion of white tissue to brown adipose tissue. But, the role of exercise on these twoimportant proteins has not been studied in subcutaneous adipose tissue.Objective: The aim of this study was to investigate the effect of continuous training on the level ofPPAR-γ and PRDM16 proteins in the adipose tissue in overweight male Sprague-Dawley rats withdiabetes.Methods: In this study, 16 two-month old Sprague-Dawley rats with an average weight of 270±20g were selected and randomly divided into two groups: control (n=8) and continuous training (n=8).The training group exercised according to the training program 4 days a week for 8 weeks while thecontrol group did not have a training program. Independent t-test was used to analyze the data.Findings: There was a significant increase in the expression of PPAR-γ (P=0.004) and PRDM16(P=0.0001) proteins in the training group compared to control group.Conclusion: Considering the increase of PPAR-γ and PRDM16 proteins in adipose tissue aftercontinuous exercise and the important role of these two proteins in the fat metabolism, aerobicexercise can be an important mechanism for reducing this tissue in obese individuals and convertingwhite tissue to brown.Keywords: Adipose tissue, Rats, Exercise, PPAR gamma, PRDM16" @default.
- W2897312639 created "2018-10-26" @default.
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- W2897312639 date "2018-08-01" @default.
- W2897312639 modified "2023-09-24" @default.
- W2897312639 title "Effect of continuous training on the level of PPAR-γ and PRDM16 proteins in adipose tissue in overweight diabetes rats" @default.
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- W2897312639 doi "https://doi.org/10.29252/qums.22.3.4" @default.
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