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- W2897312785 abstract "The purpose of this study is to describe imaging findings in a group of fetuses with suspected ASP and to evaluate the clinical outcome of these children. This is a retrospective multicentre study on a cohort of fetuses diagnosed with suspected ASP, between 2008 and 2017. The records of each patient, including US and MRI examinations were reviewed. Whenever possible, the results were compared with postnatal clinical, imaging and/or pathology findings. Forty seven patients with a diagnosis of ASP were included in the study at a mean gestational age of 26.6 weeks (range 21.0-36.3w). In 36 patients the US diagnosis was of complete and in 11 of partial ASP. In 17 patients the ASP was considered isolated and the remaining 30 had associated malformations involving the CNS (24) or other organs (6). 14 patients with isolated ASP were delivered, 13 are developing normally, one has developmental delay and three were lost to follow up. 13 patients with associated CNS malformation were delivered (normal development (5), abnormal (6) and no follow-up (2)). Nine patients opted for TOP and on two pregnancies we don't have a follow-up. From six fetuses that had ASP and only non-CNS findings, two were delivered with normal neurological development and four had TOP. MRI was performed in 29 cases. Our study demonstrated that ASP can be isolated and with a good prognosis but in the presence of associated malformations the prognosis is reserved with at least 50% risk of abnormal neurodevelopment, blindness or hormonal deficiencies. Current imaging techniques are not able to provide an accurate prognosis in cases when ASP appears isolated. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
- W2897312785 created "2018-10-26" @default.
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- W2897312785 date "2018-10-01" @default.
- W2897312785 modified "2023-10-03" @default.
- W2897312785 title "P11.03: Agenesis of the septum pellucidum: prenatal diagnosis and outcome" @default.
- W2897312785 doi "https://doi.org/10.1002/uog.19697" @default.
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