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- W2897312926 abstract "Retina is a projection of brain, and visual dysfunction (VD) thus can reflect brain disorders, like Alzheimer's disease (AD) [1]. However, relationship between (VD) and symptoms of AD remains unclear. Total 68 AD patients were continuously recruited. VD was evaluated by the thickness of retinal fiber layer (RNFL) via optical coherence tomography (OCT). According to the adjusted OCT results of age and gender of standard group (Fig 1VD was reflected by the thickness of RNFL via OCT. Green, yellow and red colors represented that visual function was 95%-5%, 5%-1% and 1%–0% of normal population, respectively.), patients were divided into AD with VD (AD-VD) and AD with no VD (AD-NVD) groups. Demographic information was recorded. Clinical symptoms were evaluated by series of rating scales for multiple cognitive domains, neuropsychological manifestations and activity of daily living (ADL). Frequency of AD-VDwas 55% (n=38).2. Age, age of onset, gender and disease duration were not different between AD-VD and AD-NVD groups (P>0.05). 3. Score of Mini-Mental State Examination (MMSE) in AD-VD group was significantly lower than that in AD-NVD group (P<0.05). Average thickness of RNFL was significantly and positively correlated with MMSE score (r=0.364, P<0.05). 4. Score of Montreal Cognitive Assessment (MoCA) in AD-VD group was significantly lower than that in AD-NVD group (P<0.05). Average thickness of the 1/4 RNFL in the right upper part（ST+SN areas in Fig 1.）was positively and significantly correlated with MoCA score (r=0.397, P<0.05). 5. Score of Verbal Fluency Test (VFT) of AD-VD group was significantly lower than that of AD-NVD group (P<0.01). 6. Score of ADL Scale of AD-VD group was significantly lower than that of AD-NVD group (P<0.05)." @default.
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- W2897312926 date "2018-07-01" @default.
- W2897312926 modified "2023-10-12" @default.
- W2897312926 title "P1‐350: RELATIONSHIP BETWEEN THICKNESS OF RETINAL FIBER LAYER AND CLINICAL SYMPTOMS OF ALZHEIMER'S DISEASE" @default.
- W2897312926 doi "https://doi.org/10.1016/j.jalz.2018.06.357" @default.
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