FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897314190> ?p ?o ?g. }

• W2897314190 endingPage "6678" @default.
• W2897314190 startingPage "6667" @default.
• W2897314190 abstract "Organ-organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common in patients with renal failure. The aim of this study was to elucidate the relationship between gastrointestinal motility and gastrointestinal symptoms in chronic kidney disease. We performed studies in C57BL/6 mice with chronic kidney disease after 5/6 nephrectomy. Gastrointestinal motility was evaluated by assessing the ex vivo responses of ileum and distal colon strips to electrical field stimulation. Feces were collected from mice, and the composition of the gut microbiota was analyzed using 16S ribosomal RNA sequencing. Mice with chronic kidney disease after 5/6 nephrectomy showed a decreased amount of stool, and this constipation was correlated with a suppressed contraction response in ileum motility and decreased relaxation response in distal colon motility. Spermine, one of the uremic toxins, inhibited the contraction response in ileum motility, but four types of uremic toxins showed no effect on the relaxation response in distal colon motility. The 5/6 nephrectomy procedure disturbed the balance of the gut microbiota in the mice. The motility dysregulation and constipation were resolved by antibiotic treatments. The expression levels of interleukin 6, tumor necrosis factor-α, and iNOS in 5/6 nephrectomy mice were increased in the distal colon but not in the ileum. In addition, macrophage infiltration in 5/6 nephrectomy mice was increased in the distal colon but not in the ileum. We found that 5/6 nephrectomy altered gastrointestinal motility and caused constipation by changing the gut microbiota and causing colonic inflammation. These findings indicate that renal failure was remarkably associated with gastrointestinal dysregulation." @default.
• W2897314190 created "2018-10-26" @default.
• W2897314190 creator A5006976615 @default.
• W2897314190 creator A5010040847 @default.
• W2897314190 creator A5018133464 @default.
• W2897314190 creator A5035550385 @default.
• W2897314190 creator A5035894974 @default.
• W2897314190 creator A5041050675 @default.
• W2897314190 creator A5043410192 @default.
• W2897314190 creator A5057985699 @default.
• W2897314190 creator A5061422743 @default.
• W2897314190 creator A5068643861 @default.
• W2897314190 creator A5089926742 @default.
• W2897314190 date "2018-10-14" @default.
• W2897314190 modified "2023-10-14" @default.
• W2897314190 title "Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility" @default.
• W2897314190 cites W104707605 @default.
• W2897314190 cites W1567357386 @default.
• W2897314190 cites W1601357544 @default.
• W2897314190 cites W1637768317 @default.
• W2897314190 cites W1904394162 @default.
• W2897314190 cites W1976884433 @default.
• W2897314190 cites W1977362933 @default.
• W2897314190 cites W1984702503 @default.
• W2897314190 cites W2004465286 @default.
• W2897314190 cites W2021576594 @default.
• W2897314190 cites W2040915108 @default.
• W2897314190 cites W2045516356 @default.
• W2897314190 cites W2051303794 @default.
• W2897314190 cites W2055323971 @default.
• W2897314190 cites W2055443487 @default.
• W2897314190 cites W2060457268 @default.
• W2897314190 cites W2078144575 @default.
• W2897314190 cites W2079616537 @default.
• W2897314190 cites W2082369700 @default.
• W2897314190 cites W2091891742 @default.
• W2897314190 cites W2094308398 @default.
• W2897314190 cites W2096947655 @default.
• W2897314190 cites W2107027176 @default.
• W2897314190 cites W2110389012 @default.
• W2897314190 cites W2116977954 @default.
• W2897314190 cites W2120027682 @default.
• W2897314190 cites W2122244729 @default.
• W2897314190 cites W2122843838 @default.
• W2897314190 cites W2125065061 @default.
• W2897314190 cites W2127313688 @default.
• W2897314190 cites W2134856187 @default.
• W2897314190 cites W2137395223 @default.
• W2897314190 cites W2139493081 @default.
• W2897314190 cites W2142293392 @default.
• W2897314190 cites W2144776566 @default.
• W2897314190 cites W2155134319 @default.
• W2897314190 cites W2155897723 @default.
• W2897314190 cites W2160716625 @default.
• W2897314190 cites W2163631890 @default.
• W2897314190 cites W2163802009 @default.
• W2897314190 cites W2165067288 @default.
• W2897314190 cites W2171060095 @default.
• W2897314190 cites W2171918809 @default.
• W2897314190 cites W2269399396 @default.
• W2897314190 cites W2466566310 @default.
• W2897314190 cites W2510093163 @default.
• W2897314190 cites W2532324289 @default.
• W2897314190 cites W2533795830 @default.
• W2897314190 cites W2560192298 @default.
• W2897314190 cites W2617232640 @default.
• W2897314190 cites W2780598835 @default.
• W2897314190 cites W788809710 @default.
• W2897314190 doi "https://doi.org/10.1002/jcp.27408" @default.
• W2897314190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30317589" @default.
• W2897314190 hasPublicationYear "2018" @default.
• W2897314190 type Work @default.
• W2897314190 sameAs 2897314190 @default.
• W2897314190 citedByCount "36" @default.
• W2897314190 countsByYear W28973141902019 @default.
• W2897314190 countsByYear W28973141902020 @default.
• W2897314190 countsByYear W28973141902021 @default.
• W2897314190 countsByYear W28973141902022 @default.
• W2897314190 countsByYear W28973141902023 @default.
• W2897314190 crossrefType "journal-article" @default.
• W2897314190 hasAuthorship W2897314190A5006976615 @default.
• W2897314190 hasAuthorship W2897314190A5010040847 @default.
• W2897314190 hasAuthorship W2897314190A5018133464 @default.
• W2897314190 hasAuthorship W2897314190A5035550385 @default.
• W2897314190 hasAuthorship W2897314190A5035894974 @default.
• W2897314190 hasAuthorship W2897314190A5041050675 @default.
• W2897314190 hasAuthorship W2897314190A5043410192 @default.
• W2897314190 hasAuthorship W2897314190A5057985699 @default.
• W2897314190 hasAuthorship W2897314190A5061422743 @default.
• W2897314190 hasAuthorship W2897314190A5068643861 @default.
• W2897314190 hasAuthorship W2897314190A5089926742 @default.
• W2897314190 hasConcept C126322002 @default.
• W2897314190 hasConcept C134018914 @default.
• W2897314190 hasConcept C2777226302 @default.
• W2897314190 hasConcept C2778260677 @default.
• W2897314190 hasConcept C2779134260 @default.
• W2897314190 hasConcept C2780091579 @default.
• W2897314190 hasConcept C2780227381 @default.

• next