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- W289731594 endingPage "90" @default.
- W289731594 startingPage "81" @default.
- W289731594 abstract "Transforming growth factor betas (TGF-βs) are multifunctional cytokines with widespread distribution. In the nervous system the biological effects of TGF-β cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF-β on mesencephalic DAergic neurons extend from induction and specification of the dopaminergic phenotype via promotion of survival to neuroprotection in animal models of parkinsonism. Experimental in vitro and in vivo models have contributed to a better understanding of the putative mechanisms underlying the effects of TGF-β on DAergic neurons and unravelled synergisms between members of the TGF-β superfamily. In this chapter, we will review the literature available with focus on TGF-β proper and glial cell-line-derived neurotrophic factor (GDNF)." @default.
- W289731594 created "2016-06-24" @default.
- W289731594 creator A5000986874 @default.
- W289731594 creator A5064076179 @default.
- W289731594 creator A5065211041 @default.
- W289731594 date "2009-01-01" @default.
- W289731594 modified "2023-09-28" @default.
- W289731594 title "TGF-β in Dopamine Neuron Development, Maintenance and Neuroprotection" @default.
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- W289731594 doi "https://doi.org/10.1007/978-1-4419-0322-8_8" @default.
- W289731594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19731553" @default.
- W289731594 hasPublicationYear "2009" @default.
- W289731594 type Work @default.