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• W2897320264 abstract "The ability to sustain attention gradually declines with age, exacerbating normal decays in performance across multiple cognitive domains. In addition, poorly sustained attention may impair efficient learning of new information and skills. Previous studies have shown that it is possible to enhance sustained attention in patients with severe impairments following acquired brain injury, and that this generalizes to improvements in spatial attention and more global cognitive improvements. Likewise, preliminary evidence has shown that enhancing sustained goal-directed attention in healthy older adults via an approach that exploits known principles of neuroplasticity (tonic and phasic attention training - TAPAT) can transfer to improvements in executive functioning and visuospatial skill learning (Van Vleet et al., 2016). While this novel approach may serve to facilitate greater benefits across a wide range of learning tasks, the neurological changes supporting these benefits are poorly understood. In the current trial we examined age-related changes in learning and plasticity pre and post TAPAT training via the PET acetylcholine ligand [18F]fluroethoxybenzovesamicol ([18F]FEOBV), a molecular agent previously employed to investigate brain diseases associated with presynaptic cholinergic losses (e.g., Alzheimer's). Participants completed approximately twelve hours of TAPAT training on iPads remotely. For the PET portion of the trial, participants were positioned lying on their back in MNI's HRRT PET. A transmission study lasting 5 minutes was performed using a 68Ge source. Subjects then received a slow push IV injection of 350-400 MBq of [18F] FEOBV (which corresponds to 8.05mSv to 9.2mSV given that the does/MBq of FEOBV are 0.023 mSv/MBq). The injected mass has been previously proven safe by Petrou et al (2014). A 60-minute list mode acquisition was launched at the start of the injection. The PET marker was produced according to the method described by Mzengeza et al (2007). Preliminary results (n = 4) demonstrated significant post-training increases in [18F]FEOBV binding from 10 - 17% in PFC, Precuneus, posterior CC and V1; and improvements in sustained attention. Intervention-related up regulation of acetylcholine suggests that participants benefitted from a simple, at-home exercise that may contribute to reduction in the potential development of age-related cognitive deficits or dementia." @default.
• W2897320264 created "2018-10-26" @default.
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• W2897320264 date "2018-07-01" @default.
• W2897320264 modified "2023-10-14" @default.
• W2897320264 title "P2‐005: NEUROPLASTICITY‐BASED VISUAL ATTENTION TRAINING AND THE EXPRESSION OF ACETYLCHOLINE IN HEALTHY OLDER ADULTS" @default.
• W2897320264 doi "https://doi.org/10.1016/j.jalz.2018.06.689" @default.
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