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- W2897320736 abstract "In this review, we present reports on the immunoregulatory properties of isoxazole derivatives classified into several categories, such as immunosuppressive, anti-inflammatory, immunoregulatory, and immunostimulatory compounds. The compounds were tested in various models using resident cells from rodents and humans, cell lines, and experimental animal disease models corresponding to human clinical situations. Beneficial features of the described isoxazole derivatives include low toxicity and good bioactivity at low doses. In a majority of studies, the activities of investigated compounds were comparable or even higher than registered reference drugs. Whenever possible, a plausible mechanism of action of the investigated compounds and their potential therapeutic utility were proposed. Among the described compounds, particular attention was paid to the class of immune stimulators with a potential application in chemotherapy patients." @default.
- W2897320736 created "2018-10-26" @default.
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- W2897320736 date "2018-10-22" @default.
- W2897320736 modified "2023-09-30" @default.
- W2897320736 title "Isoxazole Derivatives as Regulators of Immune Functions" @default.
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- W2897320736 doi "https://doi.org/10.3390/molecules23102724" @default.
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