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- W2897323252 abstract "The proteasome is an essential enzyme complex in cells whose main responsibility is to degrade proteins. Proteins can be degraded through either a ubiquitin-dependent or -independent mechanism by the proteasome. A variety of small molecules have been discovered that can increase the rate of protein degradation through either mechanism. However, stimulation of the ubiquitin-independent system is likely to be the most therapeutically impactful for protein-accumulation diseases. Preliminary evidence has demonstrated efficacy of this approach for reducing proteins associated with disease. To advance the field forward, validation of this mechanism in a disease model as well as more detailed studies on how much stimulation is required to achieve a therapeutic effect must be performed." @default.
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- W2897323252 date "2018-10-18" @default.
- W2897323252 modified "2023-10-18" @default.
- W2897323252 title "All About the Core: A Therapeutic Strategy to Prevent Protein Accumulation with Proteasome Core Particle Stimulators" @default.
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- W2897323252 doi "https://doi.org/10.1021/acsptsci.8b00042" @default.
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