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- W2897323513 endingPage "483" @default.
- W2897323513 startingPage "474" @default.
- W2897323513 abstract "Myelodysplastic syndromes (MDSs) are a myeloid neoplasm with a propensity for natural evolution or transformation to acute leukemias (AL) over time. Mechanisms for MDS transformation to AL remain poorly understood but are related to genomic instability, which affects the production of the different cell lineages. Genomic instability is also generated by dysfunctional telomeres. Indeed telomeres, the protective ends of chromosomes are the backbone of genome stability. Nuclear telomere remodeling is an early indicator of nuclear remodeling preceding the onset of genomic instability and MDS. This review aims to revisit the pathogenesis and pathophysiology of MDS from morphology and cytogenetics to molecular and epigenetic mechanisms. Furthermore, this review will highlight and discuss recent breakthroughs in dysfunctional telomeres and nuclear telomere architecture roles in the pathogenesis and physiopathology of MDS in the global context of genomic instability." @default.
- W2897323513 created "2018-10-26" @default.
- W2897323513 creator A5014225131 @default.
- W2897323513 creator A5035284000 @default.
- W2897323513 date "2018-11-18" @default.
- W2897323513 modified "2023-10-16" @default.
- W2897323513 title "From cellular morphology to molecular and epigenetic anomalies of myelodysplastic syndromes" @default.
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