FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897325901> ?p ?o ?g. }

• W2897325901 endingPage "3750" @default.
• W2897325901 startingPage "3737" @default.
• W2897325901 abstract "The antitumor activity of activated CD8+ T cells in the tumor microenvironment seems to be limited due to their being metabolically unfit. This metabolic unfitness is closely associated with T-cell exhaustion and impairment of memory formation, which are barriers to successful antitumor adoptive immunotherapy. We therefore assessed the role of glutamine metabolism in the antitumor activity of CD8+ T cells using a tumor-inoculated mouse model. The adoptive transfer of tumor-specific CD8+ T cells cultured under glutamine-restricted (dGln) conditions or CD8+ T cells treated with specific inhibitors of glutamine metabolism efficiently eliminated tumors and led to better survival of tumor-inoculated mice than with cells cultured under control (Ctrl) conditions. The decreased expression of PD-1 and increased Ki67 positivity among tumor-infiltrating CD8+ T cells cultured under dGln conditions suggested that the inhibition of glutamine metabolism prevents CD8+ T-cell exhaustion in vivo. Furthermore, the transferred CD8+ T cells cultured under dGln conditions expanded more efficiently against secondary OVA stimulation than did CD8+ T cells under Ctrl conditions. We found that the expression of a pro-survival factor and memory T cell-related transcription factors was significantly higher in CD8+ T cells cultured under dGln conditions than in those cultured under Ctrl conditions. Given these findings, our study uncovered an important role of glutamine metabolism in the antitumor activity of CD8+ T cells. The novel adoptive transfer of tumor-specific CD8+ T cells cultured in glutamine-restricted conditions may be a promising approach to improve the efficacy of cell-based adoptive immunotherapy." @default.
• W2897325901 created "2018-10-26" @default.
• W2897325901 creator A5001924975 @default.
• W2897325901 creator A5002108814 @default.
• W2897325901 creator A5003130501 @default.
• W2897325901 creator A5015709676 @default.
• W2897325901 creator A5018970044 @default.
• W2897325901 creator A5025150539 @default.
• W2897325901 creator A5030819618 @default.
• W2897325901 creator A5038248399 @default.
• W2897325901 creator A5050106408 @default.
• W2897325901 creator A5061841627 @default.
• W2897325901 date "2018-11-02" @default.
• W2897325901 modified "2023-10-17" @default.
• W2897325901 title "Reinforce the antitumor activity of <scp>CD</scp> 8 ⁺ T cells via glutamine restriction" @default.
• W2897325901 cites W1509411808 @default.
• W2897325901 cites W1672445637 @default.
• W2897325901 cites W1781304070 @default.
• W2897325901 cites W1853287186 @default.
• W2897325901 cites W1896688767 @default.
• W2897325901 cites W1968829231 @default.
• W2897325901 cites W1974811080 @default.
• W2897325901 cites W1994993231 @default.
• W2897325901 cites W1999195849 @default.
• W2897325901 cites W2015415347 @default.
• W2897325901 cites W2023952833 @default.
• W2897325901 cites W2030099809 @default.
• W2897325901 cites W2043793366 @default.
• W2897325901 cites W2052401940 @default.
• W2897325901 cites W2061610085 @default.
• W2897325901 cites W2071548401 @default.
• W2897325901 cites W2074061180 @default.
• W2897325901 cites W2079999658 @default.
• W2897325901 cites W2081061928 @default.
• W2897325901 cites W2095987251 @default.
• W2897325901 cites W2096270448 @default.
• W2897325901 cites W2099736081 @default.
• W2897325901 cites W2102906934 @default.
• W2897325901 cites W2105697998 @default.
• W2897325901 cites W2108373071 @default.
• W2897325901 cites W2117347512 @default.
• W2897325901 cites W2132667524 @default.
• W2897325901 cites W2144796561 @default.
• W2897325901 cites W2151422820 @default.
• W2897325901 cites W2153987199 @default.
• W2897325901 cites W2156145814 @default.
• W2897325901 cites W2165652595 @default.
• W2897325901 cites W2341007845 @default.
• W2897325901 cites W2522974751 @default.
• W2897325901 cites W2537834447 @default.
• W2897325901 cites W2547133566 @default.
• W2897325901 cites W2586678052 @default.
• W2897325901 cites W2606175565 @default.
• W2897325901 cites W2625852679 @default.
• W2897325901 cites W2724136428 @default.
• W2897325901 cites W2735193073 @default.
• W2897325901 cites W2735536328 @default.
• W2897325901 cites W2771485688 @default.
• W2897325901 cites W4230807240 @default.
• W2897325901 cites W4233662103 @default.
• W2897325901 doi "https://doi.org/10.1111/cas.13827" @default.
• W2897325901 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6272119" @default.
• W2897325901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30302856" @default.
• W2897325901 hasPublicationYear "2018" @default.
• W2897325901 type Work @default.
• W2897325901 sameAs 2897325901 @default.
• W2897325901 citedByCount "102" @default.
• W2897325901 countsByYear W28973259012019 @default.
• W2897325901 countsByYear W28973259012020 @default.
• W2897325901 countsByYear W28973259012021 @default.
• W2897325901 countsByYear W28973259012022 @default.
• W2897325901 countsByYear W28973259012023 @default.
• W2897325901 crossrefType "journal-article" @default.
• W2897325901 hasAuthorship W2897325901A5001924975 @default.
• W2897325901 hasAuthorship W2897325901A5002108814 @default.
• W2897325901 hasAuthorship W2897325901A5003130501 @default.
• W2897325901 hasAuthorship W2897325901A5015709676 @default.
• W2897325901 hasAuthorship W2897325901A5018970044 @default.
• W2897325901 hasAuthorship W2897325901A5025150539 @default.
• W2897325901 hasAuthorship W2897325901A5030819618 @default.
• W2897325901 hasAuthorship W2897325901A5038248399 @default.
• W2897325901 hasAuthorship W2897325901A5050106408 @default.
• W2897325901 hasAuthorship W2897325901A5061841627 @default.
• W2897325901 hasBestOaLocation W28973259011 @default.
• W2897325901 hasConcept C153911025 @default.
• W2897325901 hasConcept C154317977 @default.
• W2897325901 hasConcept C167672396 @default.
• W2897325901 hasConcept C202751555 @default.
• W2897325901 hasConcept C203014093 @default.
• W2897325901 hasConcept C2776090121 @default.
• W2897325901 hasConcept C2776107976 @default.
• W2897325901 hasConcept C2777701055 @default.
• W2897325901 hasConcept C2779349466 @default.
• W2897325901 hasConcept C502942594 @default.
• W2897325901 hasConcept C515207424 @default.
• W2897325901 hasConcept C55493867 @default.
• W2897325901 hasConcept C86803240 @default.
• W2897325901 hasConcept C8891405 @default.

• next