FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897327501> ?p ?o ?g. }

• W2897327501 abstract "Alloreactivity compromising clinical outcomes in stem cell transplantation is observed despite HLA matching of donors and recipients. This has its origin in the variation between the exomes of the two, which provides the basis for minor histocompatibility antigens (mHA). The mHA presented on the HLA class I and II molecules and the ensuing T cell response to these antigens results in graft vs. host disease. In this paper, results of a whole exome sequencing study are presented, with resulting alloreactive polymorphic peptides and their HLA class I and HLA class II (DRB1) binding affinity quantified. Large libraries of potentially alloreactive recipient peptides binding both sets of molecules were identified, with HLA-DRB1 generally presenting a greater number of peptides. These results are used to develop a quantitative framework to understand the immunobiology of transplantation. A tensor-based approach is used to derive the equations needed to determine the alloreactive donor T cell response from the mHA-HLA binding affinity and protein expression data. This approach may be used in future studies to simulate the magnitude of expected donor T cell response and determine the risk for alloreactive complications in HLA matched or mismatched hematopoietic cell and solid organ transplantation." @default.
• W2897327501 created "2018-10-26" @default.
• W2897327501 creator A5000209419 @default.
• W2897327501 creator A5002213647 @default.
• W2897327501 creator A5009809960 @default.
• W2897327501 creator A5019972031 @default.
• W2897327501 creator A5024340698 @default.
• W2897327501 creator A5025245219 @default.
• W2897327501 creator A5026300381 @default.
• W2897327501 creator A5027640245 @default.
• W2897327501 creator A5028014638 @default.
• W2897327501 creator A5039584806 @default.
• W2897327501 creator A5043033429 @default.
• W2897327501 creator A5045328383 @default.
• W2897327501 creator A5047124391 @default.
• W2897327501 creator A5052336059 @default.
• W2897327501 creator A5064818358 @default.
• W2897327501 creator A5066644705 @default.
• W2897327501 creator A5068100015 @default.
• W2897327501 creator A5085875329 @default.
• W2897327501 date "2018-10-11" @default.
• W2897327501 modified "2023-10-03" @default.
• W2897327501 title "Determining the Quantitative Principles of T Cell Response to Antigenic Disparity in Stem Cell Transplantation" @default.
• W2897327501 cites W1136838752 @default.
• W2897327501 cites W1484670487 @default.
• W2897327501 cites W1535176600 @default.
• W2897327501 cites W1966286493 @default.
• W2897327501 cites W1966342001 @default.
• W2897327501 cites W1969336096 @default.
• W2897327501 cites W1970529772 @default.
• W2897327501 cites W1973639800 @default.
• W2897327501 cites W1979731533 @default.
• W2897327501 cites W1981862374 @default.
• W2897327501 cites W1985199447 @default.
• W2897327501 cites W1998307950 @default.
• W2897327501 cites W1999210705 @default.
• W2897327501 cites W1999637787 @default.
• W2897327501 cites W2003272127 @default.
• W2897327501 cites W2004606785 @default.
• W2897327501 cites W2012169024 @default.
• W2897327501 cites W2025234168 @default.
• W2897327501 cites W2030518885 @default.
• W2897327501 cites W2041390189 @default.
• W2897327501 cites W2042057994 @default.
• W2897327501 cites W2044717166 @default.
• W2897327501 cites W2045456189 @default.
• W2897327501 cites W2067650601 @default.
• W2897327501 cites W2071817086 @default.
• W2897327501 cites W2073621589 @default.
• W2897327501 cites W2086030126 @default.
• W2897327501 cites W2092737769 @default.
• W2897327501 cites W2093146168 @default.
• W2897327501 cites W2098964986 @default.
• W2897327501 cites W2111066113 @default.
• W2897327501 cites W2111717354 @default.
• W2897327501 cites W2130796100 @default.
• W2897327501 cites W2131951386 @default.
• W2897327501 cites W2133072316 @default.
• W2897327501 cites W2133682816 @default.
• W2897327501 cites W2136091400 @default.
• W2897327501 cites W2137654247 @default.
• W2897327501 cites W2140291985 @default.
• W2897327501 cites W2141609931 @default.
• W2897327501 cites W2144401971 @default.
• W2897327501 cites W2151536540 @default.
• W2897327501 cites W2161710954 @default.
• W2897327501 cites W2164015638 @default.
• W2897327501 cites W2166213184 @default.
• W2897327501 cites W2168688111 @default.
• W2897327501 cites W2220658969 @default.
• W2897327501 cites W2258080942 @default.
• W2897327501 cites W2275205666 @default.
• W2897327501 cites W2290639160 @default.
• W2897327501 cites W2322966658 @default.
• W2897327501 cites W2324779098 @default.
• W2897327501 cites W2334668438 @default.
• W2897327501 cites W2336513938 @default.
• W2897327501 cites W2417682619 @default.
• W2897327501 cites W2423750562 @default.
• W2897327501 cites W2471645096 @default.
• W2897327501 cites W2528243887 @default.
• W2897327501 cites W2549979982 @default.
• W2897327501 cites W2589139221 @default.
• W2897327501 cites W2611670399 @default.
• W2897327501 cites W2745009709 @default.
• W2897327501 cites W2774177521 @default.
• W2897327501 cites W2774269080 @default.
• W2897327501 cites W2792236348 @default.
• W2897327501 cites W2793859699 @default.
• W2897327501 cites W2798549869 @default.
• W2897327501 cites W2897327501 @default.
• W2897327501 cites W2949553672 @default.
• W2897327501 doi "https://doi.org/10.3389/fimmu.2018.02284" @default.
• W2897327501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6193078" @default.
• W2897327501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364159" @default.
• W2897327501 hasPublicationYear "2018" @default.
• W2897327501 type Work @default.
• W2897327501 sameAs 2897327501 @default.
• W2897327501 citedByCount "10" @default.
• W2897327501 countsByYear W28973275012019 @default.

• next