Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897328810> ?p ?o ?g. }
- W2897328810 endingPage "e182320" @default.
- W2897328810 startingPage "e182320" @default.
- W2897328810 abstract "Having a child with a major birth defect can be a life-changing and stressful event that may be associated with higher cardiovascular disease (CVD) risk, yet the long-term burden of CVD for the child's mother is unknown.To assess whether mothers of an infant born with a major congenital anomaly are at higher risk of CVD compared with a comparison cohort.A population-based cohort study using individual-level linked registry data in Denmark included 42 943 women who gave birth to an infant with a major congenital anomaly between January 1, 1979, and December 31, 2013; and follow-up was conducted until 2015. A comparison group, comprising 428 401 randomly selected women, was 10:1 matched to each affected mother by maternal age, parity, and her infant's year of birth. Data analyses were performed between November 1, 2017, and February 28, 2018.Live birth of an infant with a major congenital anomaly.The primary outcome was a CVD composite outcome of acute myocardial infarction, coronary revascularization, or stroke. Secondary outcomes included individual components of the CVD composite and other cardiovascular outcomes, including unstable angina, congestive heart failure, atrial fibrillation, peripheral artery disease, ischemic heart disease, and aortic aneurysm. Cox proportional hazards regression analyses generated hazard ratios (HRs), adjusted for maternal demographic, socioeconomic, and chronic health indicators.Median maternal age at baseline was 28.8 years (interquartile range, 25.3-32.5 years). After a median follow-up of 19.5 years (interquartile range, 9.9-27.6 years), 914 women whose infant had a major congenital anomaly experienced a CVD event (1.21 per 1000 person-years; 95% CI, 1.13-1.28 per 1000 person-years) vs 7516 women in the comparison group (0.99 per 1000 person-years; 95% CI, 0.97-1.01 per 1000 person-years), corresponding to an unadjusted HR of 1.23 (95% CI, 1.15-1.32), and an adjusted HR (aHR) of 1.15 (95% CI, 1.07-1.23). Women who gave birth to an infant with multiorgan anomalies had an even higher aHR (1.37; 95% CI, 1.08-1.72). Mothers of infants with a major anomaly also had an increased aHR of the individual components of the composite outcome and the other cardiovascular outcomes.Women whose child had a major congenital anomaly experienced a 15% to 37% higher risk of premature cardiovascular disease. These women may benefit from targeted interventions aimed at improving their cardiovascular health." @default.
- W2897328810 created "2018-10-26" @default.
- W2897328810 creator A5001067933 @default.
- W2897328810 creator A5006148147 @default.
- W2897328810 creator A5012396834 @default.
- W2897328810 creator A5021399659 @default.
- W2897328810 creator A5040113589 @default.
- W2897328810 creator A5052689841 @default.
- W2897328810 creator A5055089241 @default.
- W2897328810 creator A5084136574 @default.
- W2897328810 creator A5091151828 @default.
- W2897328810 date "2018-09-21" @default.
- W2897328810 modified "2023-10-17" @default.
- W2897328810 title "Cardiovascular Disease Among Women Who Gave Birth to an Infant With a Major Congenital Anomaly" @default.
- W2897328810 cites W177499201 @default.
- W2897328810 cites W1893165902 @default.
- W2897328810 cites W1946365220 @default.
- W2897328810 cites W1975469422 @default.
- W2897328810 cites W1977367802 @default.
- W2897328810 cites W1978670003 @default.
- W2897328810 cites W1980533762 @default.
- W2897328810 cites W1987538872 @default.
- W2897328810 cites W1989770479 @default.
- W2897328810 cites W1996653323 @default.
- W2897328810 cites W2011456563 @default.
- W2897328810 cites W2016816371 @default.
- W2897328810 cites W2035977439 @default.
- W2897328810 cites W2055605011 @default.
- W2897328810 cites W2066694113 @default.
- W2897328810 cites W2069018011 @default.
- W2897328810 cites W2073101005 @default.
- W2897328810 cites W2081617479 @default.
- W2897328810 cites W2084744907 @default.
- W2897328810 cites W2088836734 @default.
- W2897328810 cites W2097529540 @default.
- W2897328810 cites W2099003584 @default.
- W2897328810 cites W2102006507 @default.
- W2897328810 cites W2102924526 @default.
- W2897328810 cites W2107057426 @default.
- W2897328810 cites W2119483110 @default.
- W2897328810 cites W2121589271 @default.
- W2897328810 cites W2122985624 @default.
- W2897328810 cites W2123539063 @default.
- W2897328810 cites W2129652475 @default.
- W2897328810 cites W2132461715 @default.
- W2897328810 cites W2140816688 @default.
- W2897328810 cites W2141625031 @default.
- W2897328810 cites W2147108549 @default.
- W2897328810 cites W2147977360 @default.
- W2897328810 cites W2149164020 @default.
- W2897328810 cites W2149720748 @default.
- W2897328810 cites W2152405977 @default.
- W2897328810 cites W2153717228 @default.
- W2897328810 cites W2155121555 @default.
- W2897328810 cites W2156693661 @default.
- W2897328810 cites W2161365979 @default.
- W2897328810 cites W2170975509 @default.
- W2897328810 cites W2201083089 @default.
- W2897328810 cites W2219591537 @default.
- W2897328810 cites W2341817708 @default.
- W2897328810 cites W2522353161 @default.
- W2897328810 cites W2523842142 @default.
- W2897328810 cites W2551469077 @default.
- W2897328810 cites W2560537841 @default.
- W2897328810 cites W2563692995 @default.
- W2897328810 cites W2740267370 @default.
- W2897328810 cites W28539586 @default.
- W2897328810 cites W2923453593 @default.
- W2897328810 cites W36186264 @default.
- W2897328810 cites W4239166088 @default.
- W2897328810 cites W4242918118 @default.
- W2897328810 cites W4246154734 @default.
- W2897328810 cites W4253652974 @default.
- W2897328810 cites W4254637496 @default.
- W2897328810 cites W4255518842 @default.
- W2897328810 cites W4320800932 @default.
- W2897328810 cites W608242090 @default.
- W2897328810 doi "https://doi.org/10.1001/jamanetworkopen.2018.2320" @default.
- W2897328810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6324496" @default.
- W2897328810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30646164" @default.
- W2897328810 hasPublicationYear "2018" @default.
- W2897328810 type Work @default.
- W2897328810 sameAs 2897328810 @default.
- W2897328810 citedByCount "11" @default.
- W2897328810 countsByYear W28973288102019 @default.
- W2897328810 countsByYear W28973288102020 @default.
- W2897328810 countsByYear W28973288102021 @default.
- W2897328810 countsByYear W28973288102022 @default.
- W2897328810 countsByYear W28973288102023 @default.
- W2897328810 crossrefType "journal-article" @default.
- W2897328810 hasAuthorship W2897328810A5001067933 @default.
- W2897328810 hasAuthorship W2897328810A5006148147 @default.
- W2897328810 hasAuthorship W2897328810A5012396834 @default.
- W2897328810 hasAuthorship W2897328810A5021399659 @default.
- W2897328810 hasAuthorship W2897328810A5040113589 @default.
- W2897328810 hasAuthorship W2897328810A5052689841 @default.
- W2897328810 hasAuthorship W2897328810A5055089241 @default.
- W2897328810 hasAuthorship W2897328810A5084136574 @default.