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- W2897330813 abstract "The last decades have been marked by an increased prevalence in non-communicable diseases such as obesity and type 2 diabetes (T2D) as well as by population aging and age-related (brain) diseases. The current notion that the brain and the body are interrelated units is gaining the attention of the scientific and medical community. Growing evidence demonstrates that there is a significant overlap in risk, comorbidity, and pathophysiological mechanisms across obesity, T2D and brain disturbances; settings that seem to be worsened when both obesity and T2D occur simultaneously, the so-called diabesity. Thereupon, there is a great concern to critically appraise and understand the mechanisms by which diabesity can affect brain responses, and may accelerate the decline in brain health. In this framework, metabolic disturbances mediated by altered insulin signaling and mitochondrial function arise among the multifactorial interactions described to occur between obesity, T2D and neurocognitive deficits. In this review we have compiled all the notions and evidence describing how diabesity negatively influences brain function putting the emphasis on insulin signaling pathway disturbances and mitochondrial anomalies. We also debate lifestyle interventions as amenable strategies to lessen metabolic anomalies and, consequently, diabesity-associated brain alterations." @default.
- W2897330813 created "2018-10-26" @default.
- W2897330813 creator A5008221500 @default.
- W2897330813 creator A5053059798 @default.
- W2897330813 date "2019-04-01" @default.
- W2897330813 modified "2023-10-09" @default.
- W2897330813 title "Diabesity and brain disturbances: A metabolic perspective" @default.
- W2897330813 cites W1483959325 @default.
- W2897330813 cites W1506717124 @default.
- W2897330813 cites W1518051697 @default.
- W2897330813 cites W1520589624 @default.
- W2897330813 cites W1546896514 @default.
- W2897330813 cites W1561112770 @default.
- W2897330813 cites W157753509 @default.
- W2897330813 cites W1590376803 @default.
- W2897330813 cites W1695648810 @default.
- W2897330813 cites W1752200684 @default.
- W2897330813 cites W181547059 @default.
- W2897330813 cites W1895530546 @default.
- W2897330813 cites W1911161994 @default.
- W2897330813 cites W1920983895 @default.
- W2897330813 cites W1964050087 @default.
- W2897330813 cites W1964532167 @default.
- W2897330813 cites W1965086719 @default.
- W2897330813 cites W1966621742 @default.
- W2897330813 cites W1970321552 @default.
- W2897330813 cites W1972638010 @default.
- W2897330813 cites W1972923809 @default.
- W2897330813 cites W1973842058 @default.
- W2897330813 cites W1975487612 @default.
- W2897330813 cites W1977897455 @default.
- W2897330813 cites W1979637734 @default.
- W2897330813 cites W1988438808 @default.
- W2897330813 cites W1989104104 @default.
- W2897330813 cites W1990253204 @default.
- W2897330813 cites W1993557388 @default.
- W2897330813 cites W2000077318 @default.
- W2897330813 cites W2004767178 @default.
- W2897330813 cites W2005343296 @default.
- W2897330813 cites W2005355670 @default.
- W2897330813 cites W2005900662 @default.
- W2897330813 cites W2013792629 @default.
- W2897330813 cites W2016523247 @default.
- W2897330813 cites W2016927879 @default.
- W2897330813 cites W2022589777 @default.
- W2897330813 cites W2024573758 @default.
- W2897330813 cites W2025028134 @default.
- W2897330813 cites W2025378252 @default.
- W2897330813 cites W2027670788 @default.
- W2897330813 cites W2028212562 @default.
- W2897330813 cites W2029906937 @default.
- W2897330813 cites W2030265072 @default.
- W2897330813 cites W2032605307 @default.
- W2897330813 cites W2034664059 @default.
- W2897330813 cites W2040517865 @default.
- W2897330813 cites W2044248209 @default.
- W2897330813 cites W2044832776 @default.
- W2897330813 cites W2047593883 @default.
- W2897330813 cites W2048589407 @default.
- W2897330813 cites W2049616256 @default.
- W2897330813 cites W2056514603 @default.
- W2897330813 cites W2057042201 @default.
- W2897330813 cites W2057843591 @default.
- W2897330813 cites W2063477088 @default.
- W2897330813 cites W2066630911 @default.
- W2897330813 cites W2068824169 @default.
- W2897330813 cites W2069158867 @default.
- W2897330813 cites W2069911669 @default.
- W2897330813 cites W2072903475 @default.
- W2897330813 cites W2073268517 @default.
- W2897330813 cites W2077468399 @default.
- W2897330813 cites W2081965230 @default.
- W2897330813 cites W2082089391 @default.
- W2897330813 cites W2083880873 @default.
- W2897330813 cites W2084034472 @default.
- W2897330813 cites W2086598037 @default.
- W2897330813 cites W2090868261 @default.
- W2897330813 cites W2094109323 @default.
- W2897330813 cites W2094727259 @default.
- W2897330813 cites W2095348888 @default.
- W2897330813 cites W2099547258 @default.
- W2897330813 cites W2101966650 @default.
- W2897330813 cites W2102796170 @default.
- W2897330813 cites W2111203511 @default.
- W2897330813 cites W2117993672 @default.
- W2897330813 cites W2119211650 @default.
- W2897330813 cites W2121830778 @default.
- W2897330813 cites W2124508932 @default.
- W2897330813 cites W2127055456 @default.
- W2897330813 cites W2130330935 @default.
- W2897330813 cites W2130568682 @default.
- W2897330813 cites W2131179613 @default.
- W2897330813 cites W2131461122 @default.
- W2897330813 cites W2136942127 @default.
- W2897330813 cites W2138692141 @default.
- W2897330813 cites W2140644522 @default.
- W2897330813 cites W2141866284 @default.
- W2897330813 cites W2142919980 @default.