Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897332261> ?p ?o ?g. }
- W2897332261 abstract "Abstract Mitochondria coordinate diverse functions within neurites, including signaling events for axonal maintenance, and degeneration. However, less is known about the role of mitochondria in axon development and maturation. Here we find that in maturing retinal ganglion cells (RGCs) in vivo, axonal mitochondria increase in size, number, and total area throughout development. We demonstrate through multiple approaches in vivo that the mechanism underlying these mitochondrial changes are dependent on eye opening and associated neuronal activity, which can be mimicked by brain derived neurotrophic factor (BDNF). We report downstream gene and protein expression changes consistent with mitochondrial biogenesis and energetics pathways, and present evidence that the associated transcripts are localized and translated at mitochondria within axons in an activity-dependent manner. Together these data support a novel model for mitochondrial-localized translation in support of intra-axonal mitochondrial dynamics and axonal maturation." @default.
- W2897332261 created "2018-10-26" @default.
- W2897332261 creator A5004501670 @default.
- W2897332261 creator A5007950712 @default.
- W2897332261 creator A5022801984 @default.
- W2897332261 creator A5024638311 @default.
- W2897332261 creator A5028704871 @default.
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- W2897332261 creator A5049260992 @default.
- W2897332261 creator A5069595836 @default.
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- W2897332261 creator A5083083160 @default.
- W2897332261 creator A5089548417 @default.
- W2897332261 creator A5091152841 @default.
- W2897332261 date "2018-10-09" @default.
- W2897332261 modified "2023-09-27" @default.
- W2897332261 title "Light-evoked activity and BDNF regulate mitochondrial dynamics and mitochondrial localized translation" @default.
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