FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2897340895> ?p ?o ?g. }

• W2897340895 abstract "Plants within the Nitrogen-fixing Clade of Angiosperms form root nodule symbioses with nitrogen-fixing bacteria. Actinorhizal plants (in Cucurbitales, Fagales, Rosales) form symbioses with the actinobacteria Frankia while legumes (Fabales) form symbioses with proteobacterial rhizobia. Flavonoids, secondary metabolites of the phenylpropanoid pathway, have been shown to play major roles in legume root nodule symbioses: as signal molecules that in turn trigger rhizobial nodulation initiation signals and acting as polar auxin transport inhibitors, enabling a key step in nodule organogenesis. To explore a potentially broader role for flavonoids in root nodule symbioses across the Nitrogen-fixing Clade, we combined metabolomic and transcriptomic analyses of roots and nodules of the actinorhizal host Datisca glomerata and legumes of the genus Medicago. Patterns of biosynthetic pathways were inferred from flavonoid metabolite profiles and phenylpropanoid gene expression patterns in the two hosts to identify similarities and differences. Similar classes of flavonoids were represented in both hosts, and an increase in flavonoids generally in the nodules was observed, with differences in flavonoids prominent in each host. While both hosts produced derivatives of naringenin, the metabolite profile in D. glomerata indicated an emphasis on the pinocembrin biosynthetic pathway, and an abundance of flavonols with potential roles in symbiosis. Additionally, the gene expression profile indicated a decrease in expression in the lignin/monolignol pathway. In Medicago sativa, by contrast, isoflavonoids were highly abundant featuring more diverse and derived isoflavonoids than D. glomerata. Gene expression patterns supported these differences in metabolic pathways, especially evident in a difference in expression of cinnamic acid 4-hydroxylase (C4H), which was expressed at substantially lower levels in D. glomerata than in a Medicago truncatula transcriptome where it was highly expressed. C4H is a major rate-limiting step in phenylpropanoid biosynthesis that separates the pinocembrin pathway from the lignin/monolignol and naringenin-based flavonoid branches. Shikimate O-hydroxycinnamoyltransferase, the link between flavonoid biosynthesis and the lignin/monolignol pathway, was also expressed at much lower levels in D. glomerata than in Medicago truncatula. Our results indicate a) a likely major role for flavonoids in actinorhizal nodules, and b) differences in metabolic flux in flavonoid and phenylpropanoid biosynthesis between the different hosts in symbiosis." @default.
• W2897340895 created "2018-10-26" @default.
• W2897340895 creator A5017059319 @default.
• W2897340895 creator A5040473141 @default.
• W2897340895 creator A5040718239 @default.
• W2897340895 creator A5041772508 @default.
• W2897340895 creator A5063276368 @default.
• W2897340895 creator A5073167370 @default.
• W2897340895 creator A5087349635 @default.
• W2897340895 date "2018-10-10" @default.
• W2897340895 modified "2023-10-17" @default.
• W2897340895 title "Distinctive Patterns of Flavonoid Biosynthesis in Roots and Nodules of Datisca glomerata and Medicago spp. Revealed by Metabolomic and Gene Expression Profiles" @default.
• W2897340895 cites W1543068333 @default.
• W2897340895 cites W1578410621 @default.
• W2897340895 cites W1611854178 @default.
• W2897340895 cites W1963989877 @default.
• W2897340895 cites W1971638507 @default.
• W2897340895 cites W1976003343 @default.
• W2897340895 cites W1978434300 @default.
• W2897340895 cites W1984658969 @default.
• W2897340895 cites W1998891319 @default.
• W2897340895 cites W2006431450 @default.
• W2897340895 cites W2006609668 @default.
• W2897340895 cites W2011081708 @default.
• W2897340895 cites W2011657487 @default.
• W2897340895 cites W2012693958 @default.
• W2897340895 cites W2021032609 @default.
• W2897340895 cites W2022814224 @default.
• W2897340895 cites W2023904752 @default.
• W2897340895 cites W2031128971 @default.
• W2897340895 cites W2032451685 @default.
• W2897340895 cites W2039285220 @default.
• W2897340895 cites W2040891760 @default.
• W2897340895 cites W2041716856 @default.
• W2897340895 cites W2047382548 @default.
• W2897340895 cites W2062922759 @default.
• W2897340895 cites W2069208773 @default.
• W2897340895 cites W2073641052 @default.
• W2897340895 cites W2077736423 @default.
• W2897340895 cites W2082825991 @default.
• W2897340895 cites W2093951078 @default.
• W2897340895 cites W2094114917 @default.
• W2897340895 cites W2101291993 @default.
• W2897340895 cites W2106997829 @default.
• W2897340895 cites W2107652659 @default.
• W2897340895 cites W2110256992 @default.
• W2897340895 cites W2110613502 @default.
• W2897340895 cites W2118588291 @default.
• W2897340895 cites W2121682074 @default.
• W2897340895 cites W2125470670 @default.
• W2897340895 cites W2127804268 @default.
• W2897340895 cites W2133714625 @default.
• W2897340895 cites W2157312621 @default.
• W2897340895 cites W2159637496 @default.
• W2897340895 cites W2160862143 @default.
• W2897340895 cites W2166070537 @default.
• W2897340895 cites W2166908288 @default.
• W2897340895 cites W2169439222 @default.
• W2897340895 cites W2172231389 @default.
• W2897340895 cites W2177317049 @default.
• W2897340895 cites W2188690658 @default.
• W2897340895 cites W2290749031 @default.
• W2897340895 cites W2322580831 @default.
• W2897340895 cites W2399990901 @default.
• W2897340895 cites W2531725911 @default.
• W2897340895 cites W2548357532 @default.
• W2897340895 cites W2590499380 @default.
• W2897340895 cites W2747342991 @default.
• W2897340895 cites W2783758974 @default.
• W2897340895 cites W2891156374 @default.
• W2897340895 cites W4211134441 @default.
• W2897340895 doi "https://doi.org/10.3389/fpls.2018.01463" @default.
• W2897340895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6192435" @default.
• W2897340895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364174" @default.
• W2897340895 hasPublicationYear "2018" @default.
• W2897340895 type Work @default.
• W2897340895 sameAs 2897340895 @default.
• W2897340895 citedByCount "28" @default.
• W2897340895 countsByYear W28973408952019 @default.
• W2897340895 countsByYear W28973408952020 @default.
• W2897340895 countsByYear W28973408952021 @default.
• W2897340895 countsByYear W28973408952022 @default.
• W2897340895 countsByYear W28973408952023 @default.
• W2897340895 crossrefType "journal-article" @default.
• W2897340895 hasAuthorship W2897340895A5017059319 @default.
• W2897340895 hasAuthorship W2897340895A5040473141 @default.
• W2897340895 hasAuthorship W2897340895A5040718239 @default.
• W2897340895 hasAuthorship W2897340895A5041772508 @default.
• W2897340895 hasAuthorship W2897340895A5063276368 @default.
• W2897340895 hasAuthorship W2897340895A5073167370 @default.
• W2897340895 hasAuthorship W2897340895A5087349635 @default.
• W2897340895 hasBestOaLocation W28973408951 @default.
• W2897340895 hasConcept C104317684 @default.
• W2897340895 hasConcept C126574351 @default.
• W2897340895 hasConcept C2776559899 @default.
• W2897340895 hasConcept C2777261093 @default.
• W2897340895 hasConcept C2777465193 @default.
• W2897340895 hasConcept C2778339097 @default.
• W2897340895 hasConcept C2779786899 @default.
• W2897340895 hasConcept C43144210 @default.

• next