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W2897345794 abstract "To provide a detailed analysis of the molecular com-ponents and underlying mechanisms associatedwith ovarian cancer, we performed a comprehensivemass-spectrometry-based proteomic characteriza-tion of 174 ovarian tumors previously analyzed byThe Cancer Genome Atlas (TCGA), of which 169were high-grade serous carcinomas (HGSCs). Inte-grating our proteomic measurements with thegenomic data yielded a number of insights into dis-ease, such as how different copy-number alterna-tionsinﬂuencetheproteome,theproteinsassociatedwith chromosomal instability, the sets of signalingpathways that diverse genome rearrangementsconverge on, and the ones most associated withshort overall survival. Speciﬁc protein acetylationsassociated with homologous recombination deﬁ-ciency suggest a potential means for stratifying pa-tients for therapy. In addition to providing a valuableresource,theseﬁndingsprovideaviewofhowtheso-maticgenomedrivesthecancerproteomeandasso-ciations between protein and post-translationalmodiﬁcation levels and clinical outcomes in HGSC." @default.
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W2897345794 date "2016-06-01" @default.
W2897345794 modified "2023-09-25" @default.
W2897345794 title "Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer" @default.
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